吕为群 教授
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发布日期:2014-04-23
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吕为群 教授

 


吕为群,男,1967年出生,河北丰润人。博士,教授,博士生导师,上海市“东方学者”特聘教授,校学术委员会委员,水生动物生理系-学术带头人、系主任,教育部重点实验室副主任。中国比较内分泌学学会、上海神经科学学会理事。曾担任国家自然科学基金委员会2017年度生命科学部专家评审组成员。水产学报、上海海洋大学学报、General Comparative Endocrinology专刊编委。长期从事适应生理学领域的科研和人才培养工作。

1989年毕业于东北农业大学食品科学学院,获学士学位。19897月至19941在中国国家乳品质量检测中心任职,从事乳品质量监控和乳品新产品开发。1998年毕业于英国利物浦JM大学,获得环境生物学博士学位。19984月至20019月受聘英国利物浦大学生物系 (University of Liverpool) Research Associate,从事甲壳动物繁殖的神经内分泌调控研究;200110月至20049月受聘英国曼彻斯特大学生物系 (University of Manchester) Research Associate200410月至20096月受聘英国曼彻斯特大学生命学院(The University of Manchester) Senior Research Scientist,从事鱼类环境适应的神经内分泌调控、神经可塑性和季节性繁殖动物生物钟调控机制方面的研究和教学工作。20096月回国就职于上海海洋大学,并于200912月受聘为上海市东方学者特聘教授;分别于20102011年入选上海市人才发展基金和上海市浦江人才计划。先后承担和参加英国BBSRCNERC、欧盟第6框架和第7框架科研计划、中国国家自然科学基金(3个面上)、高等学校博士学科点博导基金、上海市科委创新和基础重点项目、上海市教委重点科研项目。在《Current Biology》、《PNAS》、《Endocrinology》、《Animal Ecology》等国际刊物(SCI)发表学术论文63,引证数达1006次。在应激生物学和动物福利理论、生物环境适应力及其调控机制、神经可塑性、生物钟及其调控基制和海水鱼淡化养殖技术等领域享有较高的国际声誉。

教育背景

198509-198907月东北农业大学食品科学系学士学位

199401-199803月 英国利物浦JM大学分子生物学系 博士学位

教学工作情况

《动物生理学》、《动物生理学实验》、《环境与生命》、《科技英语》和全英语《鱼类生理学》。

主要研究方向

鱼类适应生理学和动物福利、个性与调控机制、响应环境变化的适应机制、环境适应力的调控机制、适应力和抗逆良种培育。

主持和参与的科教项目

[1] 中国国家自然科学基金面上项目,31572599,鱼类生殖轴与尾部神经分泌系统相互作用的研究,2016.01-2019.1275,6万元,在研,主持

[2] 中国国家自然科学基金面上项目,41376134,尾部神经分泌系统与海洋底栖鱼类适应伏底生活的关联性研究,2014.01-2017.1278万元,已结题,主持

[3]中国高等学校博士学科点专项科研基金资助课题(博导类),20113104110002,鱼类尾部神经分泌系统的发育过程与环境适应力关系的研究,2012.01-2014.1212万元,已结题,主持

[4] 2011年度上海市科委地方院校能力建设项目,11320501200,大黄鱼咸淡水和淡水养殖关建技术的研究,2012.01-2014.1260万元,已结题,参与

[5] 上海市科委浦江人才项目,11PJ1404500,鱼类尾部神经分泌系统的发育与鱼体内外环境变化的关系,2012.01-2013.1220万元,已结题,主持

[6] 中国国家自然科学基金面上项目,31072228,鱼尾部神经分泌系统受光调控的分子机制的研究,2011.01-2013.12,项目30万元,已结题,主持

[7] 欧盟FP7项目,245020,亚欧水产平台ASEM aquaculture platform- the bridge between Asianand European aquaculture2010/01-2013/1299.7万欧元,已结题,参与

[8] 上海市科技兴农重点攻关项目,沪农科攻字(2010)1-6,标准化水产养殖场不同水产品种高效生态养殖模式研究,2010/12-2013/11100万元,已结题,参与

[9] 上海市科委重点基础项目,10JC1406200,大黄鱼远缘杂交及快速生长相关基因的研究,2010/08-2013/0825万元,已结题,主持

[10] 上海市人才发展基金,2010011,银鲳在不同的生长发育阶段对环境适应力的研究,2010/12-2012/1210万元,已结题,主持

[11] 上海市教委重点创新项目,10ZZ102,鱼类盐度适应性的研究:从基因芯片到基因功能,2010/01-2012/1215万元,已结题,主持

[12] 2009年度上海市科委地方院校能力建设项目,09320503500,银鲳在不同的生长发育阶段对环境适应力的研究,2009/08-2012/08100万元,已结题,主持

[13] 上海市教育委员会,P2009030,上海市高校特聘教授(东方学者),2009/12-2012/11100万元,已结题,主持

发表的主要论文情况

[1]Huafeng Zou, Zhaohui Lan, Mo Zhou, Weiqun Lu* (2018) Promoter methylation and Hoxd4 regulate UII mRNA tissue specific expression in olive flounder Paralichthys olivaceus. General and Comparative Endocrinology. doi.org/10.1016/j.ygcen.2018.03.010

[2] Zhaohui Lan, Jinling Xu, Youji Wang, Weiqun Lu*(2018) Modulatory effect of glutamate GluR2 receptor on the caudal neurosecretory Dahlgren cells of the olive flounder, Paralichthys olivaceus. General and Comparative Endocrinology. doi.org/10.1016/j.ygcen.2018.01.017

[3] Mingzhe Yuan, Qianqian Jia, Yue Wang, Qi Lu, Langlang Tang, Youji Wang and Weiqun Lu* (2017) Dynamic responses of prolactin, growth hormone and their receptors to hyposmotic acclimation in the olive flounder Paralichthys olivaceus. General and Comparative Endocrinology,Volume 254, 1 December 2017, Pages 8-13

[4] Chunmei Ge; Weiqun Lu; aqin chen*(2017) Quantitative proteomic reveals the dynamic of protein profile during zebrafish oocyte maturation. Biochemical and Biophysical Research Communications, Volume490, Issue 3, 26 August 2017, Pages 657-663

[5] Yue Wucheng, Xiaowen Chen, Guoqing Lu, Jiao Chen, Weiqun Lu, Chenghui Wang, Shu Huang, Jun Wang (2017) Selection of appropriate reference genes for qPCR in the Chinese mitten crab, Eriocheir sinensis. Crustaceana 90(3):275-296

[6] Wu, F.L.,Hu, M.H., Gu, H.X., Kong, H., Lu,W*,Wang, Y.J.* (2017) Effects of seawater pH and temperature on foraging behavior of the Japanese stone crab Charybdis japonica. Marine Pollution Bulletin. 10.1016/j.marpolbul.2017.04.053

[7] Yingying Jin, Zhaohui Lan, Gege Zhu and Weiqun Lu*(2017) Acute salinity and temperature challenges during early development of zebrafish: Differential responses of gene expression of PTHs, PTHrPs and their receptors. Aquaculture and Fisheries, Volume 2, Issue 2, March2017, Pages 49-58

[8] Hu, M.H.,Lin, D.H., Shang, Y.Y., Hu, Y., Lu, W,Huang, X.Z., Ning, K., Chen, Y.M., Wang, Y.J.* (2017). CO2-induced pH reduction increases physiological toxicity of nano-TiO2 in the mussel Mytilus coruscus.Scientific Reports 6, 40015 DOI 10.1038/SREP40015.

[9] Lu W*, Jin Y., Xu J., Greenwood M. and Balment R (2017) Molecular characterisation and expression of parathyroid-hormone related protein in the caudal neurosecretory system of the euryhaline flounder (Platichthys flesus).J. Gen Comp Endocrinol. 249201724-31 DOI 10.1016/j.ygcen.2017.02.015

[10] Yanming Sui, Yimeng Liu, Xin Zhao, Sam Dupont, Menghong Hu, Fangli Wu, Xizhi Huang, JialeLi, Weiqun Lu*, Youji Wang* (2017) Defense responses to short-term hypoxia and seawater acidification in the thick shell mussel Mytilus coruscus. Frontiers in Physiology. 2017, 8. DOI: 10.3389/fphys.2017.00145

[11] Sui Yanming, Menghong Hu, Fangli Wu, Xizhi Huang, Sam Dupont , Daniela Storch,Hans-Otto Pörtner, Jiale Li, Weiqun Lu*,Youji Wang*. (2017) Antioxidant response of the hard shelled mussel Mytilus coruscus exposed to reduced pH and oxygen concentration. Ecotoxicology and Environmental Safety 137, 218–224.

[12] Rupia EJ, SA Binning and DG Roche and Lu W* (2016) Fight-flight or freeze-hide? Personality and metabolic phenotype mediate physiological defence responses in flatfish. Journal of Animal Ecology. 2016,85, 927–937.

[13] Xizhi Huang, Daohui Lin, Ke Ning, Menghong Hu, Weiqun Lu, Youji Wang*. Hemocyte responses of the thick shell mussel Mytilus coruscus exposed to nano-TiO2 and seawater acidification. Aquatic Toxicology,2016, 180:1-10

[14] Fangli Wu, Weiqun Lu, Hui Kong, Xizhi Huang, Yanming Sui, Menghong Hu, Youji Wang*. Combined effects of temperature and seawater acidification on the hemocyte responses in the thick shell mussel Mytilus coruscus. Fish and Shellfish Immunology, 2016 Sep;56:554-62

[15] Sui Yanming, Xizhi Huang, Hui Kong, Weiqun Lu*, Youji Wang*.(2016).Physiological responses to salinity increase in blood parrotfish (Cichlasoma synspilum ♀ × Cichlasoma citrinellum ♂). SpringerPlus. 20163;5(1):1246.

[16] Zou H, X Bai,Y Feng, Y Zhang, Y Wang,, Lu W*(2016). Influence of long (16L:8D) and short (8L:16D) photoperiods on blood metabolites and hepatic metabolism in Japanese flounder, Paralichthys olivaceus. Springerplus. (2016), 5(1), 1-7.

[17] Sui Yanming, Hui Kong, Xizhi Huang, FangLi Wu, Menghong Hu, Weiqun Lu*, Youji Wang*. Effects of short-term hypoxia and seawater acidification on hemocyte responses of the mussel Mytilus coruscus. Marine Pollution Bulletin 108 1-22016 46-52.

[18] Sui Yanming, Hui Kong, Xizhi Huang, Sam Dupont, Menghong Hu, Daniela Storch,Hans-Otto Pörtner, Weiqun Lu*, Y Wang*. (2016). Combined effects of short-term exposure to elevated CO2 and decreased O2 on the physiology and energy budget of the thick shell mussel Mytilus coruscus. Chemosphere 155 (2016) 207-216.

[19] Zhao H,Zou H and Lu W * (2016) Ploidy polymorphism and morphological variation among reciprocal hybrids by Pseudosciaena crocea (♀) × Miichthys miiuy (♂). Aquaculture Research , 47(11)2016, 3390–3398

[20] Wang Y, W Zhang, W Li, Lu W* (2016) Effects of salinity on the physiological responses of the large yellow croaker Pseudosciaena crocea under indoor culture conditions.Aquaculture Research, 2016, 47(11):3410-3420

[21] Huang S,J Wang, W Yue, J Chen, S Gaughan, G Lu, W Lu, C Wang* (2016) Transcriptomic variation of hepatopancreas reveals the energy metabolism and biological processes associated with molting in Chinese mitten crab, Eriocheir sinensis. Scientific Reports , 2015; 5: 14015

[22] Wang Y,Q Guo, H Zhao, H Liu, Lu W* (2015)Larval development and salinity tolerance of Japanese Flounder (Paralichthys olivaceus) from hatching to juvenile settlement. Aquaculture Research, 2015,46,1878-1890.

[23] Sui Yanming, Hu Menghong, Huang Xizhi, Wang Youji, Lu Weiqun * (2015) Anti-predatory responses of the thick shell mussel Mytilus coruscus exposed to seawater acidification and hypoxia. Marine Environmental Research, 2015,109:159-167

[24] Menghong Hu, Lisha Li, Yanming Sui, Jiale Li, Youji Wang, Lu Weiqun *, Sam Dupont (2015) Effect of pH and temperature on antioxidant responses of the thick shell mussel Mytilus coruscus. Fish & Shellfish Immunology, 2015,46(2):573-583

[25] Li L, Lu W, Sui Y, Y Wang * (2015) Conflicting effects of predator cue and ocean acidification on the mussel Mytilus coruscus byssus production. Journal of Shellfish Research,2015,34(2):393-400

[26] Li L, W Lu*, Y Wang (2015) Anti-predatory responses of the thick shell mussel Mytilus coruscus exposed to seawater acidification and thermal stress. Journal of Experimental Marine Biology and Ecology.

[27] Wang Y,Lisha Li, M Hu, Lu W * (2015)Physiological energetics of the thick shell mussel Mytilus coruscus exposed to seawater acidification and thermal stress. Science of the Total Environment(2015) 514 261–272

[28] Luo L,Chen A, Hu C and Lu W* (2014) Dynamic expression pattern of corticotropin-releasing hormone, urotensin I and II genes under acute salinity and temperature challenge during early development of zebrafish. Fish physiology and biochemistry 2014;40:1877-1886.

[29] Rupia EJ, Wu J, Chen W, Dierckens K, Sorgeloos P and Lu W* (2014) Effect of hormone injection frequency on the lipid content and fatty acid compositions in gonad, muscle and liver of Anguilla japonica during artificial maturation. Aquaculture International2013;22:1105-1120.

[30] Wang Y,M Hu, Q Li, J Li, D Lin, Lu W*(2014) Immune toxicity of TiO(2) under hypoxia in the green-lipped mussel Perna viridis based on flow cytometric analysis of hemocyte parameters. Science of The Total Environment 2014;470-471, 791–799

[31] Tao X*,C Wang, H Wei, Z Ren, X Ma, Lu W (2014) Effects of dietary cholesterol levels on moulting performance, lipid accumulation, ecdysteroid concentration and immune enzymes activities of juvenile Chinese mitten crab Eriocheir sinensis. Aquac Nutr 2014;20:467-476.

[32] Wang,G., M. Yagi, R. Yin, Lu W and A.Ishimatsu* (2014) Effects of elevated seawater CO2 on feed intake, oxygen consumption and morphology of Aristotle’s lantern in the sea urchin Anthocidaris crassispina. J Mar Sci Technol-Taiwan 2013;21:192-200.

[33] Lu W*, Y Zhang, J Xiong and R J.Balment (2013) Daily rhythms of hormone secretion and gene expression of urotensin I and II in the caudal neurosecretory system of the euryhaline flounder (Platichthys flesus). Gen Comp Endocrinol. 188189-195:.

[34] Zhao H,X Liu and Lu W* (2013) Isolation and characterization of 12 new polymorphic microsatellite markers in the miiuy croaker (Miichthys miiuy) genome. Journal of Genetics 92, e77–e80

[35] Wang Y,L Li, G Cui, Lu W* (2013) Ontogenesis from embryo to juvenile and salinity tolerance of Japanese devil stinger Inimicus japonicus during early life stage. Springerplus 2013, 2:289

[36] Wang Y,Hu M, Cheung S, Shin P, Lu W, Li J (2013) Anti-predatory responses of Perna viridis (linnaeus) under acute hypoxia and low salinity. Journal of Molluscan Studies 79, 42–50.

[37] Wang Y,M Hu, S Cheung, P Shin, Lu W, J Li (2012) Immune parameter changes of hemocytes in green-lipped mussel Perna viridis exposure to hypoxia and hyposalinity. Aquaculture 356–357: 22–29

[38] Wang Y,M Hu, S Cheung, P Shin, Lu W, J. Li(2012) Chronic hypoxia and low salinity impair anti-predatory responses of the green-lipped mussel Perna viridis. Marine Environmental Research 77 (2012):84-89

[39] Li J, Lu W, S. Beesley, A. Loudon and Q. Meng(2012) Lithium impacts on the molecular circadian clockwork through induction of Period2 transcription. PloS one 7 (3):1-8

[40] Lu W*, Mayolle A, Cui G, Luo L and Balment R J (2011) Molecular characterization and expression of α-globin and β-globin genes in the Euryhaline Flounder, Platichthys flesus. Evidence-Based Complementary and Alternative Medicine vol. 2011: 965153

[41] McMasterA, Jangani M , P Sommer, Han N, Brass A , LuW, A Berry, Beesley S, L Zeef, A Loudon, R Donn and D Ray (2011) Ultradian cortisol pulsatility encodes a distinct, biologically important signal. PloSone 6 (1):1-9

[42] Meng Q, Maywood E, Bechtold D, Lu W, Li J,Sládek M1, Ohren J, Walton K, Walters T, Hastings M,Loudon A (2010) Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes. PNAS107(34):15240-5.

[43] Lu W, Q Meng, N Tyler, K Stokkan &A Loudon (2010) A circadian clock is not required in an arctic mammal. Current Biology20533-537.

[44] Huang X,Yin Y, Shi Z, Li W, Zhou H, Lv W2010Lipid content and fatty acid composition in wild-caught silver pomfret (Pampus argenteus) broodstocks: Effects on gonad development. Aquaculture 310:192-199

[45] Meng Q,McMaster A, Beesley S, Lu W, Parks D, Collins J, Farrow S, Ray D, Loudon A. (2008) A novel Rev-erbα ligand resets the peripheral clock in a phasic manner - insight into retinoid regulation of the circadian clock. J. Cell Science, 121: 3629-35.

[46] Marley R, Lu W, Balment R J and McCrohan CR. (2008) Cortisol and Prolactin Modulation of Caudal Neurosecretory System Activity in the Euryhaline Flounder Platichthys flesus. Comp. Biochem. Physiol.Part A 151:71–77.

[47] Lu W., A.E.S. Abdel-Razik, N. Ashton,R.J. Balment (2008) Urotensin II: Lessons from comparative studies for general endocrinology. Gen Comp Endocrinol, 157(1):14-20.

[48] Lu W, Balment RJ, Riccardi D and McCrohan CR (2007) Seasonal changes in peptide, receptor and ion channel expression in the caudal neurosecretory system of the European flounder,Platichthys flesus. Gen Comp Endocrinol. 153(1-3):262-72.

[49] Marley R, Lu W, Balment RJ and McCrohan CR(2007) Evidence for a role for nitric oxide in the caudal neurosecretory system of the European flounder, Platichthys flesus. Gen Comp Endocrinol. 153(1-3):251-61.

[50] McCrohan CR, Lu W, Brierley MJ, Dow L and Balment RJ (2007) Fish caudal neurosecretory system: a model for the study of neuroendocrine secretion. Gen Comp Endocrinol. 153(1-3): 243-50.

[51] Abbink W, Bevelander GS, Hang X, Lu W,Guerreiro PM, Spanings T, Canario AV, Flik G. (2006.9) PTHrP regulation and calcium balance in sea bream (Sparus auratus L.) under calcium constraint. JExp Biol. 15; 209(18): 3550-7

[52] Lu W, Greenwood M, Dow L, Yuill J,Worthington J, McCrohan CR, Riccardi D and Balment RJ (2006) Molecular characterisation and expression of Urotensin II and its receptor in the flounder (Platichthys flesus): a hormone system supporting body fluid homeostasis in euryhaline fish. Endocrinology 147(8): 3692-3708.

[53] Balment RJ, Lu W, Bond H, Weybourne E and Warne JM (2006.5) Arginine Vasotocin a key hormone in fish salt and water balance and many other aspects of physiology and behaviour. Gen Comp Endocrinol. 144: 240-247.

[54] Song W,Abdel-Razik AES, Lu W, Ao Z, Johns DG, Douglas SA, Balment RJ and Ashton N (2006.4) Urotensin II and renal function in the rat. Kidney International, 69(8):1360-8.

[55] Warne JW, Bond H, Weybourne E, Sahajpal V, LuW, and Balment RJ (2005) Altered plasma and pituitary arginine vasotocin, and hypothalamic provasotocin expression in flounder (Platichthys flesus) following hypertonic challenge, distribution of vasotocin receptors within the kidney. Gen Comp Endocrinol,144:240-247.

[56] Lu W., Dow L., Gumusgoz s., Brierley MJ, Warne JW, McCrohan CR, Balment RJ and Riccardi D. (2004) Co-expression of corticotropin-releasing hormone (CRH) and urotensin I (UI) precursor genes in the caudal neurosecretory system of the euryhaline flounder (Platichthys flesus):a possible shared role in peripheral regulation. Endocrinology, 145 (12),5786-5797.

[57] Brierley M, Bauer C, Lu W, Riccardi D,Balment R and McCrohan C (2004) Voltage- and Ca2+- dependent burst generation in neuroendocrine Dahlgren cells in the teleost Platichthys flesus. J.Neuroendocrinol. 16, 832-841.

[58] Brierley M, Ashworth A, Craven T, Woodburn M, Banks J, Lu W, Riccardi D, Balment R and McCrohan C (2003) Electrical activity of caudal neurosecretory neurons in seawater and freshwater adapted flounder: responses to cholinergic agonists. J. Exp. Biol. 206; 4011-4020.

[59] Lu W, Wainwright G, Olohan L, Webster S,Rees H and Tuner P (2001) Characterization of cDNA encoding molt-inhibiting hormone of the crab, Cancer pagurus: expression of MIH in non-X-organ tissues.Gene, 278, 149-159.

[60] Lu W, Wainwright G, Webster S, Rees Hand Tuner P (2000) Clustering of Mandibular Organ-Inhibiting Hormone and Moult-Inhibiting Hormone genes in the crab, Cancer pagurus and implications for regulation of expression. Gene, 253, 197-207.

[61] Tang,C., Lu W, Wainwright, Webster, S.G., Rees, H.H. and Tuner, P.C. (1999) Molecular characterisation and expression of Mandibular Organ-Inhibiting Hormone, a recently discovered neuropeptide involved in the regulation of growth and reproduction in the crab, Cancer Pagurus. Biochem. J. 343, 355-360.

[62] Lu W, V Saunders, E Evans. (1997) Identification of cyanobacteria by polymorphisms of PCR-amplified ribosomal DNA spacer region, FEMS Microbiology Letters, 153: 141-149.

申请和授权专利情况

[1]夏华;吕为群;戴习林等弹簧式捕鱼装置, ZL 2012 2 0218154.4. 实用新型专利2013/05/16

[2]夏华;吕为群;戴习林等一种专捕小型鱼的撒网, ZL 2012 2 0135085.0. 实用新型专利2012/11/21

[3]吕为群;黄旭雄;陈阿琴等一种鲳鱼低盐养殖方法, ZL 2012 1 0188622.2. 发明专利2013/12/04

[4] 王帅;吕为群;陈阿琴等封闭式组织研磨棒装置, ZL 2013 2 0030046.9. 实用新型专利 2013/07/24

[5] 王帅;吕为群;陈阿琴等直线型批量组织脱水装置, ZL 2013 2 0029688.7. 实用新型专利2013/07/24

[6]吕为群;李兵等一种大黄鱼工厂化低盐养殖方法, ZL 2012 1 0148204.0 发明专利2014/04/02

[7] 程若冰、吕为群等一种用于生物实验的低温固定平台, ZL 2013 2 0631805.7. 实用新型专利2014/04/16

[8] 王有基, 李丽莎,吕为群,胡梦红,张冬晓,沙毅杰,一种贻贝足丝的固着装置,ZL201320256494.0

[9]王有基, 李丽莎,胡梦红,吕为群,黄茜枝,王灿,一种海水中二氧化碳浓度可控的贝类养殖装置,ZL201420111678.2

[10] 兰兆辉吕为群秦逸凡许金玲魏泓毓,一种用于体外电生理记录的低温平台, ZL 2016 10033675.5发明专利 2017/06/16

联系方式

地址:上海市临港新城沪城环路999号生命学院A311

电话:021-61900448

Email: wqlv@shou.edu.cn

2018年3月更新)