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发布日期:2014-04-10
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严继舟 教授


严继舟 医学博士,教授,生物系生物技术教研室。上海细胞生物学学会理事、学术委员会委员。九三学社社员。

1980年至1988年就读武汉大学医学部医学系和病原生物学专业,先后获医学学士和硕士学位。1993年至1995年获中英科技合作项目资助在英国伦敦大学伦敦卫生和热带医学学院(London School of Hygiene and Tropical Medicine)进修血清流行病学和分子生物学。1996-1999年攻读第二军医大学病原生物学博士获医学博士学位。20006后研究资助,主要研究转基因技术和斑马鱼发育基因组学。20053月应聘美国宾夕法尼亚大学医学院 (University of Pennsylvania School of Medicine )研究助理(Research Associate),从事小鼠胚胎干细胞的培养和造血干细胞定向分化以及抑癌基因表观遗传学和信号转导研究。20093月回国就职于上海海洋大学水产与生命学院、上海海洋大学海洋科学研究院海洋生物系统和神经科学研究所。

  

教学工作

[1] 本科教学:主讲《生物化学》,《生物化学实验》和《营养与疾病》。

[2] 研究生教学:主讲《生物工程原理与技术》和《组织细胞培养理论与技术》

科研方向

淡水和海水生物在营养和生物医学研究的开发应用:水生生物组织再生和细胞可塑性的生理生化特征。目前研究课题:

[1] 海星和大闸蟹再生相关的生物活性物质分离与鉴定;

[2] 斑马鱼心脏和下颌组织完全再生的细胞转分化及结构重建的分子机制;

[3] 引导性腺细胞转分化和再生的sox9-信号通路调节;

  

代表性论文

[1] Lan Wei, Ling Huang, Jinghui Cao, Chenghui Wang and Jizhou Yan*. Dietary safety Assessment of lk1-Transgenic Fish。。Frontiers in Physiology January 2018 9 | Article 8.

[2] Hui Zhang, Wen Wen, Jizhou Yan*. Application of immunohistochemistry technique in hydrobiological studies. Aquaculture and Fisheries 2 (2017) 140e144

[3] Yancen Dai, Nagarajan Prithiviraj, Jianhong Gan, XinA. ZhangJizhou Yan*Tissue Extract Fractions from Starfish Undergoing Regeneration Promote Wound Healing and Lower Jaw Blastema Regenerationof ZebrafishScientific Reports2016,6, 38693; doi: 10.1038/srep38693

[4] Xin He, Lei Wang, JizhouYan, Chaoxing Yuan, Eric S. Witze, and Xianxin Hua. Menin localization in cell membrane compartment.Cancer Biology & Therapy 2016;17 (1): 114-122.

[5] Jin Feng,Chao Huang, Jonathan D. Wren, Dao-Wen Wang,Jizhou Yan, Jiexin Zhang, Yujie Sun, Xiao Han, Xin A. Zhang. Tetraspanin CD82: a suppressor of solid tumors and a modulator of membrane heterogeneity.Cancer Metastasis Rev 2015; 34:619–633.

[6] Hui Zhang, Xuelong Wang, Kailun Lyu,Siqi Gao, Guan Wang , Chunxin Fan, Xin A. Zhang Jizhou Yan*.Time point-based integrative analyses of deep-transcriptome identify four signal pathways in blastemal regeneration of zebrafish lower jaw.Stem Cells 2015;33806-8181

[7] Dongjie Sun, Yin Zhang, Chen Wang, Xianxin Hua, XinA. Zhang, Jizhou Yan*. Sox9-related signaling controls zebrafish juvenile ovary-testis transformation. Cell Death& Diseases 2013; 4, e930

[8] Xuelong Wang, Huihui He, Wenqiao Tang, Xin A.Zhang, Xianxin Hua, Jizhou Yan* Two origins of blastemal progenitors define blastemal regeneration of zebrafish lower jaw.PloS One, 2012;79:e45380

[9]Huihui He,Xianxin Hua, Jizhou Yan*. Epigenetic regulations in hematopoietic Hox code. Oncogene,2011;30:379-388

[10] Austin T. Thiel, Peter Blessington, Tao Zou, Danielle Feather, Xinjiang Wu, Jizhou Yan, Hui Zhang, Zuguo Liu, Patricia Ernst, Gary A. Koretzky, and Xianxin Hua. MLL-AF9-induced leukemogenesis requires co-expression of the wild type Mll allele. Cancer Cell, 2010;17(2):148- 59

[11] Jizhou Yan, Yuqing Yang, Hui Zhang,Catrina King, H-M Kan, C-X Yuan, GS Bloom and X Hua. Menin interacts with IQGAP1 to enhance intercellular adhesion of beta cells. Oncogene. 2009;28 (7):973.

[12] Jizhou. Yan*, Xiang Yang, MarkA. Martin, Mohammed Shahabuddin. Malaria sporozoite antigen-directed genome-wide responses in transgenic Drosophila.Genesis, 2009; 473):196.

  

专著和教材

[1] Gene Regulatory Networks : Methods and Protocols (Editors: Bart Deplancke,Nele Gheldof).Jizhou Yan, Shawn Burgess. Using a yeast inverse one-hybrid system to identify functional binding sites of transcription factors. Methods Mol Biol. 2012;786:275-290

[2] 李志勇主编《细胞工程实验》1吕恺伦、严继舟*. 第三篇 细胞工程综合实验-第六章动植物人工繁殖-实验二十 鱼类精子冻存与体外受精;(2高思琪、严继舟*第四篇 前沿探索实验-实验四十三 用斑马鱼受精卵建立人类疾病模型。高教出版社,2016

[3]《健康与疾病的营养基因组学研究》,严继舟、王晓杰编著, 学苑出版社,2018年,北京。

  

优秀本科生进实验室

1.李乐诗、浦逸晟、马嘉怡(指导老师:严继舟)Pax3a多肽在细胞治疗中的作用。第一届全国大学生生命科学竞赛二等奖

2.一种通过体表注射斑马鱼性腺的简易投药方法。杜新路,吴嘉诚,陆,严继舟。上海海洋大学学报, 2018, 27(1):24-28

3.Dietary safety Assessment of lk1-Transgenic Fishlan Wei, Ling Huang,Jinghui Cao, Chenghui Wang and Jizhou Yan. Frontiers in Physiology 2018  9 | Article 8魏雅岚,黄玲

4.多巴胺和γ-氨基丁酸在斑马鱼损伤性组织再生的表达特征分析。杨钦,王箕雨,吴昊,严继舟。 基因组学与应用生物学,201736 1):201-209

5.四种氨基酸神经递质对斑马鱼胚胎发育和成体组织再生的双重影响. 李心雨,刘亚平,杜新路,严继舟。淡水渔业,2017475):19-25.

6.在斑马鱼仔鱼脑部异体移植胚胎细胞的尝试。曹静晖,魏雅岚,严继舟. 淡水渔业, 淡水渔业,2016464):1-6.

7.Tissue Extract Fractions from Starfish Undergoing Regeneration Promote Wound Healing and Lower Jaw Blastema Regeneration of Zebrafish. Yancen Dai1,*, Nagarajan Prithiviraj2,*, Jianhong Gan3,4, Xin A. Zhang5 & Jizhou Yan1,2 Scientific Reports 2016 6:38693 |Jincao Zeng参与工作,在呈谢里有注明。曾进超

8.Time Point-Based Integrative Analyses of Deep-Transcriptome Identify Four Signal Pathways in Blastemal Regeneration of Zebrafish Lower Jaw. HUI ZHANG, XUELONG WANG, KAILUN LYU, SIQI GAO, GUAN WANG, CHUNXIN FAN,XIN A. ZHANG, JIZHOU YAN. STEM CELLS 2015;33:806818 . Jinghui Cao, and Xiaoyun Zhou参与工作,在呈谢里有注明。高思琪、曹静晖、周晓云

9.两个Sox9 基因在斑马鱼胚胎发育和成体性腺中的动态表达特征。梁清仪,王心仪,孙冬捷,严继舟。山东农业科学201446( 7) : 20  24

10.Ul trastructural Observation and Neurotransmitter Analysis of Tissue Regeneration afterAmputation of Zebrafish Lower Jaw. Hao Wu, Li Li, Xianrui Li,Jiyu Wang, Danqun Chen, Jizhou YanHans Journal of Agricultural Sciences 农业科学, 2014, 4, 73-80。李先瑞、王琪雨

11.转基因斑马鱼侧线系统的形成及其对新霉素的抗性。邵贝丽,严继舟。淡水渔业,2014441):41-45.

12.Sox9-related signaling controls zebrafish juvenile ovary-testis transformation. Dongjie Sun, Ying Zhang, Chen Wang, Xianxin Hua, Xin A. Zhang, JizhouYan*. Cell Death & Diseases 2013; 4, e930. 王晨

  

联系方式:电话 021-61900488; E-mail:jyan2@shou.edu.cn

20183月更新)