基本情况

李文豪，博士，水产种质与育种系副教授，上海市教委“水产种质资源挖掘和良种创制战略创新团队”，江苏省“双创团队”成员。主要承担《水产生物统计学》、《分子生物学》、《基因工程》等课程的教学工作。主持国自然青年基金，国家实验室开放基金等各类科研项目。曾获得海洋科学技术奖一等奖（极地鱼类适应性进化机制研究）。发表论文20余篇, 主要论文以第一/通讯作者(含共同)发表在BMC Biology (x2), Molecular Ecology Resources, Zoological Research, The FEBS Journal等杂志上。Aquaculture, Water Biology and Security, Fish Physiology and Biochemistry, Frontiers in Ecology and Evolution等国内外期刊审稿人。

教育工作背景

2017.07--2019.08，上海海洋大学水产养殖学博士后流动站，博士后

2012.09--2017.06，上海海洋大学理学博士，生物学（硕博连读）

2008.09--2012.06，河南师范大学农学学士，水产养殖学

主要研究方向

1.鱼类耐低温的分子机制与耐低温新品种育种的遗传基础

2.鱼类比较基因组学及演化生物学

主持和参与的科教项目

[1] 国家自然科学基金委，青年科学基金，RNA编辑在鱼类低温适应中的功能研究，32400418，2025.01-2027.12，主持，在研

[2] 国家自然科学基金委，面上项目，两种极端环境海洋鱼类心脏发育的分子进化机制比较研究，32470557，2025.01-2028.12，参与，在研

[3] 科技创新2030, 农业生物育种，优质速生鱼新品种设计与培育, SQ2023AAA020230，2023-09至2025-12, 参与，在研

[4] 国家重点研发计划，海洋农业与淡水渔业科技创新，耐高温大口黑鲈和抗链球菌病罗非鱼新品种培育，2022-11 至2026-12，参与，在研

发表的主要论文情况

[1] Wenhao Li#, Jie Song#, Huaming Tu#, Shouwen Jiang#, Binbin Pan, Jiazhen Li, Yongpeng Zhao, Liangbiao Chen*, Qianghua Xu*. Genome sequencing of Coryphaenoides yaquinae reveals convergent and lineage-specific molecular evolution in deep sea adaptation, Molecular Ecology Resources, 2024, 24, e13989.

[2] Wenhao Li#, Zhiqiang Li#, Mengdi Bu#, Jiazhen Li, Liangbiao Chen*, Metabolomic-based analysis reveals bile acid-mediated ovarian failure induced by low temperature in zebrafish, Zoological Research, 2024, 45(4): 791-804.

[3] Wenhao Li#, Mengdi Bu#, Ruiqin Hu, Shouwen Jiang, Liangbiao Chen* and George N. Somero*. Tissue-specific temperature dependence of RNA editing levels in zebrafish. BMC Biology, 2023, 21(1), 262.

[4] Ying Lu#, Wenhao Li#, Yalin Li#, Wanying Zhai#, Xuming Zhou#, Zhichao Wu, Shouwen Jiang, Taigang Liu, Huamin Wang, Ruiqin Hu, Yan Zhou, Jun Zou, Peng Hu, Guijun Guan, Qianghua Xu*, Adelino V.M. Canário*, Liangbiao Chen*. Population genomics of an icefish reveals mechanisms of glacier-driven adaptive radiation in Antarctic Notothenioids. BMC Biology, 2022, 20(1), 231.

[5] Liangbiao Chen#, Ying Lu#, Wenhao Li#, Yandong Ren, Mengchao Yu, Shouwen Jiang, Yanxia Fu, Jian Wang, Sihua Peng, Kevin T. Bilyk, Katherine R. Murphy, Xuan Zhuang, Mathias Hune, Wanying Zhai, Wen Wang, Qianghua Xu*, Chi-Hing Christina Cheng*. The genomic basis for colonizing the freezing Southern Ocean revealed by Antarctic toothfish and Patagonian robalo genomes. GigaScience, 2019, 8(4), giz016.

[6] Wenhao Li, Faxiang Wang, Shouwen Jiang, Binbin Pan, Qi Liu, Qianghua Xu*. Morphological and molecular evolution of hadal amphipod’s eggs provides insights into embryogenesis under high hydrostatic pressure. Frontiers in Cell and Developmental Biology, 2022, 10:987409. 

[7] Wenhao Li#, Faxiang Wang#, Shouwen Jiang, Binbin Pan, Jiulin Chan, Qianghua Xu*. The Adaptive Evolution and Gigantism Mechanisms of the Hadal “Supergiant” Amphipod Alicella gigantea. Frontiers in Marine Science, 2021, 8:743663.

[8] Xi Li#, Xinwen Li#, Wenhao Li#, Yingqing Zhang, Haiyan Guo, Guangxing Wang, Yayuan Li, Xiaowen Wu, Ruiqin Hu, Siyu Wang, Xiaomiao Zhao, Liangbiao Chen*, Guijun Guan*. Sex-specific meiosis response to Gsdf in medaka (Oryzias latipes). The FEBS Journal, 2023, 290(10): 2760-2779.

[9] Xin Zhang, Zhichao Wu, Mengdi Bu, Ruiqin Hu, Xiaowen Zhang, Wenhao Li*, Liangbiao Chen*. The CCAAT/Enhancer Binding Protein Beta (cebpb) is essential for the development of enveloping layer (EVL) in zebrafish. Aquaculture and Fisheries, 2023, 8(3): 252-260.

[10] Bingshe Han#, Wenhao Li#, Zuozhou Chen#, Qiongqiong Xu, Juntao Luo, Yingdi Shi, Xiaoxia Li, Xiaonan Yan, Junfang Zhang*. Variation of DNA methylome of zebrafish cells under cold pressure. PloS One, 2016, 11(8), e0160358.

[11] Hongying Hao#, Baolu Shi#, Jiacheng Zhang#, Ao Dai#, Wenhao Li#, Haidi Chen, Wenya Ji, Chenjia Gong, Chang Zhang, Jing Li, Li Chen, Bin Yao, Peng Hu, Hao Yang, Juergen Brosius, Shanshan Lai*, Qinghua Shi*, Cheng Deng*. The vertebrate- and testis- specific transmembrane protein C11ORF94 plays a critical role in sperm-oocyte membrane binding. Mol Biomed, 2022, 3(1): 1-18.

[12] Lang Gui#, Wenjie Lu#, Mijuan Shi#, Ruiqin Hu, Yan zhou, Yubang Shen, Xiaoyan Xu, Jie Liu, Huimin Xia, Yaping Wang, Wenhao Li*, Ying Lu*. Liver DNA methylation and transcriptome between 1-and 3-year-old grass carp. Aquaculture and Fisheries. 2022, 7(3): 269-277.

[13] Qianqian Yan, Wenhao Li, Xiaoting Gong, Ruiqin Hu, Liangbiao Chen*. Transcriptomic and Phenotypic Analysis of CRISPR/Cas9-Mediated gluk2 Knockout in Zebrafish. Genes, 2022, 13(8): 1441.

[14] Tao Zhou#, Lang Gui#, Mingli Liu, Wenhao Li, PengHu, Daniel F.C. Duarte, HongboNiu, Liangbiao Chen*. Transcriptomic responses to low temperature stress in the Nile tilapia, Oreochromis niloticus. Fish & Shellfish Immunology, 2019, 84, 1145-1156.

[15] Jian Wang#, Yimeng Liu#, Shouwen Jiang, Wenhao Li, Lang Gui, Tao Zhou, Wanying Zhai, Zixuan Lin, Jiaying Lu, Liangbiao Chen*. Transcriptomic and epigenomic alterations of Nile tilapia gonads sexually reversed by high temperature. Aquaculture, 2019, 508, 167-177.

[16] Shue Chen, Mengchao Yu, Xu Chu, Wenhao Li, Xiujuan Yin, Liangbiao Chen*. Cold-induced retrotransposition of fish LINEs. Journal of Genetics and Genomics, 2017, 44(8), 385-394.

[17] Yan Zhou#, Yanjie Zhang#, Shang Wei, Wei Li, Wenhao Li, Zhichao Wu, Shouwen Jiang, Ying Lu, Qianghua Xu, Liangbiao Chen*. Reduced Hypoxia Tolerance and Altered Gill Morphology at Elevated Temperatures May Limit the Survival of Tilapia (GIFT, Oreochromis niloticus) under Global Warming. Fishes, 2022,7(5), 216.

[18] Mingli Liu, Ruiqin Hu, Wenhao Li, Wenyi Yang, Qianghua Xu, Liangbiao Chen*. Identification of Antibacterial Activity of Hepcidin from Antarctic Notothenioid Fish. Frontiers in Microbiology, 2022, 13:834477.

[19] 李文豪,冉皓宇,陈良标.低温胁迫导致斑马鱼尾部发育畸形的分子机制[J].基因组学与应用生物学,2018,37(06):2383-2388.DOI:10.13417/j.gab.037.002383. (Li, W., Ran, H., & Chen, L. (2018). Molecular mechanism of zebrafish tail developmental malformation caused by low temperature stress. Genomics and Applied Biology, 37(6), 2383-2388.)

科教工作获奖情况

[1] 2020年, 海洋科学技术奖“一等奖”, 极地鱼类适应性进化机制研究, 第8完成人(8/15)；

[2] 2021年, 入选江苏省双创团队；

[3] 2019年，上海海洋大学科学技术奖“三等奖”，斑马鱼细胞低温适应的表观遗传调控机制研究，第4完成人（4/7）；

[4]  2021年，上海海洋大学人事考核优秀；

[5] 2025年，大学生创新训练项目，RNA可变剪接在罗非鱼低温耐受中的功能及作用机制研究，“校级立项”（指导教师）。

联系方式

地址：海洋科技大楼10楼1004室

E-mail：wh-li@shou.edu.cn