祖尧，博士，教授。上海市青年东方学者、晨光学者、扬帆计划等人才计划获得者。先后主持国家自然科学基金青年项目、面上项目，国家重点研发计划项目任务等十余项科研项目。发表论文四十余篇，其中以第一或通讯作者在Nature Methods（被引400余次）、Nature Communications、Cell Mol Life Sci等领域TOP期刊发表论文。以第一发明人获得国家发明专利5件，专利转化1件。培养多名研究生获得国家奖学金和上海市优秀毕业生。

教育科研经历

2018.01—2021.02，哈佛大学，访问学者；

2013.02—2014.02，美国UCLA，联合培养博士；

2009.09—2014.07，北京大学生命科学学院, 硕博连读；

研究方向：

从事遗传与发育生物学基础研究，主要进行基因编辑技术与高通量筛选技术的开发，构建斑马鱼模型研究心血管与低氧耐受调控机制，及其水产基因编辑分子育种的应用。

主持和参与的主要项目

[1] 国家自然科学基金 32170423，主持，2022/ 01—2025 / 12

[2] 国家自然科学基金31501166，主持，2016 / 01—2018 / 12

[3] 国家重点研发计划青年科学家项目2024YFD2402400，子任务主持，2024/12—2027/11

[4] 上海市教委青年东方学者项目 QD2020039，主持，2021/01—2023/12

[5] 上海市教委晨光学者项目14CG49， 2015 / 01—2017 / 12

[6] 上海市科委扬帆人才计划15YF1405000，主持，2015 / 01—2017 / 12

[7] 上海市人才发展资金201568，主持，2016 / 01—2018 / 12

[8] 海洋生物临港科创平台项目ZY-2024-0001, 主持，2024/10-2025/12

[9] 海洋生物临港科创平台项目，ZY-2023-0001, 主持，2023/01-2023/12

[10] 海洋生物临港科创平台项目，ZY-2022-0001, 主持，2022/01-2022/12

发表的主要论文情况

[1] Wang, J., Shi, H., Wang, C., Zhao, Y.*, & Zu, Y.*. (2025). High-Throughput Zebrafish Screening Reveals Cardiotoxic Effects of Organophosphate Flame Retardants. Environmental Research, 120960.  

[2] Liu, K., Zhu, Y., Gao, W., Han, X., Zhang, Q., Zhao, Y.*, & Zu, Y*. (2024). Resveratrol alleviates heart failure by activating foxo3a to counteract oxidative stress and apoptosis. Biomedicine & Pharmacotherapy, 181, 117716.

[3] Zhu, Y., Chen, Y., & Zu, Y*. (2024). Leveraging a neutrophil-derived PCD signature to predict and stratify patients with acute myocardial infarction: from AI prediction to biological interpretation. Journal of Translational Medicine, 22(1), 612.

[4] Zuo, S., Shi, H., Zu, Y*., ... Zhao, Y*. (2024). Reduced transcriptome analysis in zebrafish uncovers disruptors of spliceosome and ribosome biosynthesis. Science of The Total Environment, 952, 175967.

[5] Zhu, Y., Chen, Y., Xu, J., & Zu, Y*. (2024). Unveiling the Potential of Migrasomes: A Machine-Learning-Driven Signature for Diagnosing Acute Myocardial Infarction. Biomedicines, 12(7).

[6] Lu, J., Zhu, Y., Wei, S., Huang, S., Zu, Y.*, & Chen, L*. (2024). Comprehensive transcriptome analysis unravels the perturbated cardiovascular-related molecular mechanisms of tilapia under high-temperature stress. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 52, 101324.

[7] Zhu, Y., Chen, B., &Zu, Y*. (2024). Identifying OGN as a Biomarker Covering Multiple Pathogenic Pathways for Diagnosing Heart Failure: From Machine Learning to Mechanism Interpretation. Biomolecules, 14(2), 179. https://doi.org/10.3390/biom14020179，2024, 14,179.

[8] Hu, P., Wang, B., Jin, D., Gu, Y., He, H., Meng, X., Zhu, W., Chiang, D. Y., Li, W., MacRae, C. A., &Zu, Y*. (2023). Modeling of large-scale hoxbb cluster deletions in zebrafish uncovers a role for segmentation pathways in atrioventricular boundary specification. Cellular and molecular life sciences : CMLS, 80(11), 16

[9] Wang, H., He, J., Han, X., Wu, X., Ye, X., Lv, W., & Zu, Y*. (2023). hoxa1a-Null Zebrafish as a Model for Studying HOXA1-Associated Heart Malformation in Bosley-Salih-Alorainy Syndrome. Biology, 12(7), 899.  

[10] Zhu, Y., &Zu, Y*. (2023). Comprehensive Bioinformatics Analysis Reveals PTPN1 (PTP1B) Is a Promising Immunotherapy Target Associated with T Cell Function for Liver Cancer. Journal of healthcare engineering, 2023, 11.19

[11] Wang J, Zhang L, Tao N, Wang X, Deng S, Li M, Zu Y*, Xu C*. Small Peptides Isolated from Enzymatic Hydrolyzate of Pneumatophorus japonicus Bone Promote Sleep by Regulating Circadian Rhythms. Foods. 2023 Jan 19;12(3):464.

[12] Zhu, Y., Yang, X., &Zu, Y*. (2022). Integrated analysis of WGCNA and machine learning identified diagnostic biomarkers in dilated cardiomyopathy with heart failure. Frontiers in cell and developmental biology.

[13] Han, X., Wang, B., Jin, D., Liu, K., Wang, H., Chen, L., &Zu, Y*. (2022). Precise Dose of Folic Acid Supplementation Is Essential for Embryonic Heart Development in Zebrafish. Biology.

[14] Hu, P., Zhao, X., Zhang, Q., Li, W., &Zu, Y*. (2018). Comparison of Various Nuclear Localization Signal-Fused Cas9 Proteins and Cas9 mRNA for Genome Editing in Zebrafish. G3 (Bethesda, Md.)

[15] Zu, Y*., Zhang, X., Ren, J., Dong, X., Zhu, Z., Jia, L., Zhang, Q., & Li, W. (2016). Biallelic editing of a lamprey genome using the CRISPR/Cas9 system. Scientific reports.

[16] Tong, X., Zu, Y.*, Li, Z., Li, W., Ying, L., Yang, J., ... & Zhang, B. (2014). Kctd10 regulates heart morphogenesis by repressing the transcriptional activity of Tbx5a in zebrafish. Nature Communications, 5(1), 3153.27.

[17] Zu, Y*., Tong, X., Wang, Z., Liu, D., Pan, R., Li, Z., ... & Lin, S. (2013). TALEN-mediated precise genome modification by homologous recombination in zebrafish. Nature Methods, 10(4), 329-331.29.

授权专利情况

[1] 祖尧，王宏杰.  高效构建基因组大片段删除突变体的方法和应用（授权专利：CN202210758278.X）

[2] 祖尧,武秀知,贺经纬.hoxaa基因簇缺失斑马鱼突变体的制备方法和应用（授权专利：CN202210760745.2）

[3] 祖尧,贺经纬.hoxa1a基因敲除斑马鱼突变体的构建方法和应用（授权专利：CN202210760760.7）

[4] 祖尧,王冰琦. 斑马鱼心脏发育相关基因簇缺失突变体中主效基因的筛选方法和应用(授权专利: CN202210760738.2)

[5] 祖尧,武秀知,杨小静,王宏杰. 微卫星重复序列敲除突变体的构建方法和应用(授权专利: CN202210760655.3)

[6] 任建峰，黄姣，霍锦倩，刘姣，祖尧，李伟明. 斑马鱼糖原贮积症gys1 和 gys2 基因突变体的构建方法（授权专利：ZL 201910090967.6）

[7] 张庆华，时灿，岳倩文，祖尧，李伟明. ddx27基因缺失斑马鱼突变体的制备方法（授权专利 ：ZL 201810525964.6）

联系方式

地址：上海市浦东新区沪城环路999号

E-mail：yzu@shou.edu.cn

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