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发布日期:2014-04-30
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李名友 研究员


李名友,男,博士,生于19772月,研究员。2000.9-2008.6,中国科学院水生生物研究所学习,获遗传学博士学位。2003.12-2008.6,新加坡国立大学生物系联合培养博士、研究助理;2008.7-2013.7,新加坡国立大学生物系博士后;2013.9加入上海海洋大学水产与生命学院生物技术教研室鱼类干细胞实验室。分别于2015年入选上海市“浦江人才”计划和2016年入选上海市“曙光学者”计划。

  

教学工作:

承担本科生《组织学与发育生物学》和《组织胚胎学实验》等课程的教学工作

研究方向:

以模式生物青鳉鱼(medaka)为研究对象,从事鱼类生殖发育生物学和干细胞生物学的研究,建立方法学,并将其应用于水产经济鱼类育种研究。主要包括以下三个方面:1.鱼类生殖细胞研究;2.鱼类干细胞研究;3.鱼类遗传育种。

主持和参与项目

[1]国家自然科学基金面上项目,31672700、建立青鳉囊胚移植技术开辟鱼类异体生殖的新途径、2017/01-2020/12、主持。

[2]上海市曙光计划,青鳉生殖细胞的移植研究、2017/01-2019/12、主持。

[3]上海市浦江计划,15PJ1403100dazl基因调控青鳉生殖细胞发育和可育性的功能和机制研究、2015/07-2017/06、主持。

[4]国家自然科学基金面上项目,31372520piwi 调控青鳉生殖细胞和眼睛发育的机理研究、2014/01-2017/12、主持。

[5]上海市教委高校新进老师启动费,A1-2035-14-0010-4piwi在神经系统的表达和功能研究2014/09-2016/09、主持。

[6]上海海洋大学高层次人才引进项目,B-5008-12-0110-2、鱼类生殖细胞与干细胞研究、2014/01-2018/12、主持。

[7]国家重点基础研究发展计划973 项目,2010CB126304、重要养殖鱼类功能基因组和分子设计育种的基础研究,2010/01-2014/12,参加。

发表论文#共同第一作者,*通讯作者)

[1]Li M, Hong N, Xu H, Song J, Hong Y*.Germlinereplacement by blastula cell transplantation in the fish medaka. Sci Rep. 2016 Jul 13; 6:29658. (IF5.2)

[2]Li M, Zhu F, Li Z, Hong N,Hong Y*. Dazl is a criticalplayer for primordial germ cell formation in medaka. Sci Rep. 2016 Jun 22; 6: 28317. (IF5.2)

[3]Hong N#, Li M#, Yuan Y, Wang T, Yi M, Xu H, Zeng H,Song J*, Hong Y*.Dnd Is a Critical Specifier of Primordial Germ Cells in the Medaka Fish. Stem Cell Reports. 2016 Mar 8;6(3):411-21. (IF7.0)

[4]Li M, Zhao H, Wei J, Zhang J, Hong Y*. Medaka vasa gene has anexonic enhancer for germline expression. Gene. 2015; 555(2): 403-408. (IF2.1)

[5]Li M#, Zhu F#, Hong L, Zhang L, Hong Y*. Alternative transcription generatesmultiple Mitf isofroms with different expression pattern and activities inmedaka. Pigment Cell & Melanoma Research. 2014; 27 (1): 48-58. (IF5.8)

[6]Li M, Zhu F, Hong Y*. Differential evolution ofduplicated medakafish mitf genes. Int J Biol Sci. 2013; 9(5): 496-508. (IF4.3)

[7]Li M, Guan G, Hong N,Hong Y*. Multiple regulatory regions control the transcription of medaka germgene vasa. Biochimie. 2013; 95 (4): 850-7. (IF3.1)

[8]Li M, Yuan Y, Hong Y*.Identification of the RNAs for Transcription Factor Mitf as a component of theBalbiani Body. J Genet Genomics. 2013; 40(2): 75-81. (IF2.9)

[9]Li M, Hong N, Gui J*,Hong Y*. Medaka piwi is essential for primordial germ cell migration. CurrMol Med. 2012; 12(8): 1040-9. (IF5.2)

[10]Li M#, Shen Q#,Xu H, Wong FM, Cui J, Li Z, Hong N, Wang L, Zhao H, Ma B, Hong Y*. Differentialconservation and divergence of fertility genes boule and dazl inthe rainbow trout. PLoS One. 2011; 6(1): e15910. (IF4.1)

[11]Li M#, Shen Q#,Wong F, Xu H, Hong N, Zeng L, Liu L, Guan G, Hong N, Hong Y*. Germ cell sexprior to meiosis in the rainbow trout. Protein & Cell. 2011; 2(1):48-54. (IF3.2)

[12]Li M, Hong N, Xu H, YiM, Li C, Gui J, Hong Y*. Medaka vasa is required for migration but notsurvival of primordial germ cells. Mech Dev. 2009; 126 (5-6): 366-81. (IF3.5)

[13]Zhang X#, Guan G#,Li M, Zhu F, Liu Q, Naruse K, HerpinA, Nagahama Y, Li J*, Hong Y*. Autosomal gsdf acts as a male sex initiator in the fish medaka.Sci Rep. 2016 Jan 27; 6:19738.( IF5.2)

[14]Liu R, Li M, Li Z, Hong N, Xu H, Hong Y*. Medaka Oct4 is Essential for Pluripotency in Blastula Formation and ESCell Derivation. Stem Cell Rev. 2015 Feb;11(1): 11-23. (IF3.2)

[15]Yuan Y, Li M, Hong Y*. Light and electron microscopic analyses of Vasa expression in adult germcells of the fish medaka. Gene. 2014 Jul 15; 545(1):15-22. (IF2.1)

[16]Li Z, Li M, Hong N, Yi M, Hong Y*. Formation and cultivation of medaka primordial germ cells. Cell TissueRes. 2014 Jul; 357(1):71-81.(IF3.2)

[17]Yuan Y, Li M, Hong N, Hong Y*. Correlative light and electron microscopicanalyses of mitochondrial distribution in blastomeres of early fish embryos. FASEB J. 2014 Feb; 28(2): 577-85. (IF5.6)

[18]Yan Y, Hong N, Chen T, Li M,Wang T, Guan G, Qiao Y, Chen S, Schartl M, Li CM, Hong Y*. p53 genetargeting by homologous recombination if fish ES cells. PLoS One. 2013;8(3): e59400. (IF4.1)

[19]Lin F, Liu Q, Li M, Li Z, HongN, Li J, Hong Y*. Transient and stable GFP expression in germ cells by the vasaregulatory sequences from the red seabream (Pagrus major). Int J Biol Sci.2012; 8(6): 882-90. (IF3.2)

[20]Zhao H, Li M, Purwanti YI, Liu R, Chen T, Li Z, Hong N, Guan G, Yin A, XiaoL, Ge R, Song J, Hong Y*. Mitf is a transcriptional activator of medaka germgenes in culture. Biochimie. 2012; 94(3): 759-67. (IF3.7)

[21]Rao F, Wang T, Li M, Li Z, Hong N, Zhao H, Yan Y, Lu W, Chen T, Wang W, Lim M,Yuan Y, Liu L, Zeng L, Wei Q, Guan G, Li C, Hong Y*. Medaka tert producesmultiple variants with differential expression in vitro and in vivo. Int JBiol Sci. 2011; 7(4): 426-39. (IF3.2)

[22]Xu H, Li M, Gui J*, Hong Y*.Fish germ cells. Sci China Life Sci. 2010; 53 (4): 435-46. (IF2.0)

[23]Hong N, Li M, Zeng Z, Yi M, DengJ, Gui J, Winkler C, Schartl M, Hong Y*. Accessibility of host cell lineages tomedaka stem cells depends on genetic background and irradiation of recipientembryos. Cell Mol Life Sci. 2010; 67(7): 1189-1202. (IF6.1)

[24]Liu L, Hong N, Xu H, Li M, YanY, Purwanti Y, Yi M, Li Z, Wang L, HongY*. Medaka dead end encodes a cytoplasmic protein and identifiesembryonic and adult germ cells. Gene Expr Patterns. 2009; 9(7): 541-8. (IF2.1)

[25]Xu H, Li Z, Li M, Wang L, HongY*. Boule is present in fish bisexually expressed in adult and embryonic germcells of medaka. PLoS One. 2009; 4(6): e6097. (IF4.3)

[26]Yan Y, Du J, Chen T, Yi M, Li M, Wang S, Li CM, Hong Y*.Establishment of medaka fish as a model for stem cell based gene therapy:efficient delivery and potential chromosomal integration by baculoviralvectors. Exp Cell Res. 2009; 315 (13): 2322-31. (IF3.6)

[27]Xu H, Li M, Gui J, Hong Y*. Cloning and expression of medaka dazl duringembryogenesis and gametogenesis. Gene Expr Patterns. 2007; (3): 332-8. (IF2.1)

[28]徐红艳,李名友, 桂建芳*, 洪云汉*. 鱼类生殖细胞. 中国科学: 生命科学, 2010;40 (2):124-138.

[29]汲广东,李名友,周莉, 桂建芳*. 斜带石斑鱼囊胚期胚胎和尾芽期胚胎差异表达基因的筛选及克隆, 动物学研究, 2006, 27 (5): 461-472.

[30]朱新平,杜合军, 周莉, 李名友, 桂建芳*. 乌龟遗传多样性的RAPD分析, 水生生物学报, 2005, 29 (2): 167-171.

[31]李名友,周莉, 杨林, 刘静霞, 桂建芳*. 彭泽鲫的分子遗传分析及其与方正银鲫A系的比较, 水产学报. 2002, 26(5): 472-476.

联系方式:

地址:上海市浦东新区沪城环路999号,上海海洋大学水产与生命学院A317

邮编:201306

电话:+86-021-6190 0494

邮箱:myli@shou.edu.cn

  

201611月更新)