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发布日期:2014-06-28
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韩兵社 副研究员

  

  

韩兵社,男,19767月出生于山西省阳城县,博士,副研究员。生物系生物技术教研室。2007年于中国医学科学院基础医学研究所获得博士学位以后,以博士后和访问学者在美国佛罗里达大学,Emory大学和马里兰大学从事科研工作,发表SCI 论文多篇,其中第一作者论文发表在Cancer Cell(影响因子:23.523),PLOS ONE(影响因子: 3.234)等期刊,PLOS ONE 审稿人。

 

教育背景

2003/09-2007/07,中国医学科学院基础医学研究所/北京协和医科大学基础医学院,生物化学系,博士

1999/09-2002/07,山西医科大学基础医学院,生物化学系,硕士

1994/09-1999/07,山西医科大学,临床医学系,学士

教学工作情况

参与本科生“基因组学”课程的讲授

主要研究方向

目前的主要研究方向:

[1]miR-202在鱼类生殖发育过程中的生物学功能研究;

[2]自噬(Autophagy)在鱼类寒冷适应过程中的功能研究;

[3]热休克蛋白对鱼类表观遗传学机制的影响。

主持和参与的科教项目

[1]上海市自然科学基金“miR-202在鱼类生殖发育过程中的生物学功能研究13ZR1419500),2013,主持

[2]国家基金委重点项目“青藏高原裂腹鱼类的分子进化和高原适应的机制研究”(31130049),2012,参加

[3]国家自然科学基金面上项目“鱼类寒冷环境下逆转座子大规模扩增的表观遗传调控机制研究”(31372516),2014,参与

发表的主要论文情况

[1]Han B*, Park D*, Li R*, Xie M*, Owonikoko TK, Zhang G, Sica GL, Ding C, Zhou J, Magis AT, Chen ZG, Shin DM, Ramalingam SS, Khuri FR, Curran WJ, Deng X. Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy. Cancer Cell. 2015 27(6): 852–863.*co-first author

[2]Hu P, Liu M, Zhang D, Wang J, Niu H, Liu Y, Wu Z, Han B, Zhai W, Shen Y, Chen L. Global identification of the genetic networks and cis-regulatory elements of the cold response in zebrafish. Nucleic Acids Res. 2015. 43(19):9198-213.

[3]Balasubramanian S, Scharadin TM, Han B, Xu W, Eckert RL. The Bmi-1 helix-turn and ring finger domains are required for Bmi-1 antagonism of (-) epigallocatechin-3-gallate suppression of skin cancer cell survival. Cell Signal. 2015; 27(7):1336-44.

[4]Han B, Rorke EA, Adhikary G, Chew YC, Xu W, Eckert RL. Suppression of AP1 transcription factor function in cultured keratinocytes and murine epidermis alters gene expression. PLoS One. 2012;7(5):e36941.

[5]S Balasubramanian S, Kanade S, Han B, Eckert RL. A proteasome inhibitor-stimulated Nrf-1-dependent proteasome subunit gene expression reduces polycomb group protein level J Biol Chem. 2012 Oct 19;287(43):36179-89

[6]Choudhury SR, Balasubramanian S, Chew YC, Han B, Marquez VE, Eckert RL Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells. Carcinogenesis. 2011; 32(10):1525-32

[7]Han B, Ren Y, Guan L, Wei W, Hua F, Yang Y, Yang T, Cao T, Dong H, Pan H, Xu C.Sodium selenite induces apoptosis in acute promyelocytic leukemia-derived NB4 cells through mitochondria-dependent pathway. Oncol Res. 2009;17(8):373-81.

[8]Guan L, Han B, Li J, Li Z, Huang F, Yang Y, Xu C. Exposure of human leukemia NB4 cells to increasing concentrations of selenite switches the signaling from pro-survival to pro-apoptosis.Ann Hematol. 2009;88(8):733-42

[9]Guan L, Han B, Li Z, Hua F, Huang F, Wei W, Yang Y, Xu C. Sodium selenite induces apoptosis by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction in human acute promyelocytic leukemia NB4 cells. Apoptosis. 2009;14(2):218-25.

[10]Guan L, Huang F, Li Z, Han B, Jiang Q, Ren Y, Yang Y, Xu C P53 transcription-independent activity mediates selenite-induced acute promyelocytic leukemia NB4 cell apoptosis. BMB Rep. 2008; 41(10):745-50.

[11]Han B, Wei W, Hua F, Cao T, Dong H, Yang T, Yang Y, Pan H, Xu C. Requirement for ERK activity in sodium selenite-induced apoptosis of acute promyelocytic leukemia-derived NB4 cells. J Biochem Mol Biol. 2007; 40(2):196-204.

[12]Dong H, Ying T, Li T, Cao T, Wang J, Yuan J, Feng E, Han B, Hua F, Yang Y, Yuan J, Wang H, Xu C.Comparative proteomic analysis of apoptosis induced by sodium selenite in human acute promyelocytic leukemia NB4 cells. J Cell Biochem. 2006; 98(6):1495-506.

[13]Wei Wei, Bingshe Han, Liying Guan Li-ying Guan, Fang Huang, Lei Feng, Yang Yang, Cai-min Xu. Mitochondrial transmembrane potential loss caused by reactive oxygen species plays a major role in sodium selenite-induced apoptosis in NB4 cells. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2007; 29 (3):324-8

[14]Yang Yang, Chen Lan, Han Bingshe, Xu Caimin. Construction and Expression of Various Human Prion Proteins Mutants with Modified N-glycosylation Sites in Mammalian Cells. Chinese Journal of Biotechnology. 2006; 22(3): 373-7

[15]Cao TM, Hua FY, Xu CM, Han BS, Dong H, Zuo L, Wang X, Yang Y, Pan HZ, Zhang ZN.Distinct effects of different concentrations of sodium selenite on apoptosis, cell cycle, and geneexpression profile in acute promyeloytic leukemia-derived NB4 cells. Ann Hematol. 2006 Jul;85(7):434-42.

联系方式

地址:水产与生命学院A117

电话:15618063219

E-mailbs-han@shou.edu.cn

 

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