桂朗，女，1984年10月生，籍贯湖北，博士，水产养殖专业教授、硕士生导师。水产生理与医学系。中国水产学会淡水养殖分会委员，核心期刊《水生生物学报》首届青年编委，《微生物学通报》期刊编委，《Animals》期刊客座编委。

教育科研背景

2013/01-至今，上海海洋大学，水产与生命学院。

2010/09-2012/09，比利时根特大学（University of Ghent, Belgium），生命科学院，博士后，导师Peter Bossier教授。

2006/09-2010/09，中国科学院海洋研究所，实验海洋生物学重点实验室，硕博联读博士，导师相建海研究员。

2002/09-2006/06，武汉大学，生命科学学院，学士。

教学工作情况

承担的本科生课程组织胚胎学、组织胚胎学实验、专业英语等。

主要研究方向

长期从事水产动物病害防控的研究与应用，进行病害早期检测技术的开发。利用鱼类生殖干细胞操作等前沿技术，为降低养殖鱼类生殖周期长导致的养殖成本、助力保护濒危鱼类、进行性别控制及抗病育种等方面提供技术支持。

主持和参与的项目

[1] 2022-12至2026-12 “海洋农业与淡水渔业科技创新”国家重点专项“精原干细胞体外诱导与基因编辑结合的鱼类精准性控技术”项目（2022YFD2401600）200万，主持。

[2] 2021-07至2024-06 上海市2021年度“科技创新行动计划”自然科学基金面上项目“鲫疱疹病毒肿瘤坏死因子受体（CaHV-TNFR）与宿主相互作用的的分子机制”（21ZR1427200）20万，主持。

[3] 2018-12至2022-12 国家重点研发项目“重要养殖生物对典型环境胁迫的响应机制和生理生态效应研究”子课题“养殖生物应对温度胁迫的生理和发育响应机制与生态效应研究”（2018YFD0900601）30万，主持。

[4] 2018-12至2022-12国家重点研发计划“重要水产养殖生物抗病和抗逆性状的遗传基础与调控机制”子课题“淡水鱼类抗病与抗逆性状形成的分子机理”（2018YFD0900302）,参与。

[5]2017-01至2020-12国家自然科学基金面上项目“建立青鱂囊胚移植技术开辟鱼类异体生殖的新途径”（31672700），参与。

[6]2016-01至2018-12国家自然科学基金青年基金“基于弹涂鱼多型卵黄蛋白原评价环境雌激素活性的研究”（41506193），参与。

[7]2015-01至2017-12国家自然科学基金青年基金“长链非编码RNA在金钱鱼性腺发育过程中功能的初步研究”（41406156），参与。

[8]2014-01至2016-12国家自然科学基金青年基金“铁调素在金钱鱼铁代谢中的作用机理研究”（31302214）23万，主持。

[9]2014年淡水生态与生物技术国家重点实验室开放基金“通过构建金钱鱼肝细胞株进行铁超载差异表达基因的研究 ”（2014FB02）10万，主持。

发表的主要论文情况

[1] Zhou Y#, Gui L#, Wei W, Xu E, Zhou W, Sokolova I, Li M*, Wang Y*. Low particle concentrations of nanoplastics impair the gut health of medaka. Aquatic toxicology, 2023, 256, 106422. (IF5.202)

[2] Liu D#, Gui L#, Zhu Y, Xu C, Zhou W, Li M. Chromosome-Level Assembly of Male Opsariichthys bidens Genome Provides Insights into the Regulation of the GnRH Signaling Pathway and Genome Evolution. Biology, 2022, 11(10), 1500. (IF5.168)

[3] Zhou T, Fang Z, Duarte, D.F.C, Fernandes, S.A., Lu Y, Guo J, Gui, L*, Chen L*. Transcriptome Analysis of Immune Response against Streptococcus agalactiae Infection in the Nile Tilapia GIFT Strain. Fishes 2022, 7, 246. (IF3.17)

[4] Gui L, Zhao Y, Xu D, Luo J, Zhou W, Li M. Quick detection of Carassius auratus herpesvirus (CaHV) by recombinase-aid amplification lateral flow dipstick (RAA-LFD) method. Frontiers in Cellular and Infection Microbiology. 2022 Sep 12;12:981911. (IF6.073)

[5] Xu C, Li Y, Wen Z, Jawad M, Gui L*, Li M*. Spinyhead Croaker Germ Cells Gene dnd Visualizes Primordial Germ Cells in Medaka. Life. 2022; 12(8):1226. (IF3.253)

[6] Xia J, Liu D, Zhou W, Yi S, Wang X, Jawad M, Xu H, Gui L, Li M*. Comparative transcriptome analysis of brain and gonad reveals reproduction-related miRNAs in the giant prawn, Macrobrachium rosenbergii. Frontiers in Genetics. 2022 Aug 26;13:990677. (IF4.772)

[7] Wang M, Xia J, Jawad M, Wei W, Gui L, Liang X, Yang J, Li M. Transcriptome sequencing analysis of sex-related genes and miRNAs in the gonads of Mytilus coruscus. Frontiers in Marine Science. 2022, 9:1013857.

[8] Wei W, He J. Yaqoob M, Gui L, Ren J, Li J, Li M. Integrated mRNA and miRNA Expression Profile Analysis of Female and Male Gonads in Acrossocheilus fasciatus. Biology. 2022,11,1296.

[9] Tang R, Xu C, Zhu Y, Yan J, Yao Z, Zhou W, Gui L*, Li M*. Identification and expression analysis of sex biased miRNAs in Chinese hook snout carp Opsariichthys bidens. Frontiers in Genetics. 2022 Sep 2;13:990683. (IF4.772)

[10] Chen X, Kan Y, Zhong Y, Jawad M, Wei W, Gu K, Gui L*, Li M*. Generation of a normal long-term-cultured Chinese Hook Snout Carp spermatogonial stem cell line capable of sperm production in vitro. Biology. 2022; 11(7):1069. (IF5.168)

[11] Kan Y, Zhong Y, Jawad M, Chen X, Liu D, Ren M, Xu G, Gui L*, Li M*. Establishment of a Coilia nasus gonadal somatic cell line capable of sperm induction in vitro. Biology. 2022; 11(7):1049. (IF5.168)

[12] Gui L, Li X, Lin S, Zhao Y, Lin P, Wang B, Tang R, Guo J, Zu Y, Zhou Y*, Li M*. Low-Cost and Rapid Method of DNA Extraction from Scaled Fish Blood and Skin Mucus. Viruses. 2022 Apr 18;14(4):840.(IF5.818)

[13] Chen X#, Zhu Y#, Zhu T, Song P, Guo J, Zhong Y, Gui L*, Li M*. Vasa identifies germ cells in embryos and gonads of Oryzias celebenis. Gene. 2022 May 20; 823:146369. (IF3.913)

[14] Gui L, Xu L, Liu Z, Zhou Z, Sun Z. (2022). Carotenoid-rich microalgae promote growth and health conditions of Artemia nauplii. Aquaculture. Volume 546: 737289. (IF5.135)

[15] 柯飞#,桂朗#,李涛,张奇亚. (2021). 克氏原螯虾白斑病毒株(WSSV- Cc)基因组的一个印迹. 水产学报. 45(9):1491-1499.

[16] Song P#, Sun B#, Zhu Y, Zhong Y, Guo J, Gui L*, Li M*. Bucky ball induces primordial germ cell increase in medaka. Gene, 2021 Feb 5;768:145317. (IF3.913)

[17] Ke F#, Gui L#, Li T, Li F, Zhao X, Chen Z, Lei C, Zhang Q. (2021). The features of an emerging whispovirus isolate from freshwater crayfish. Aquaculture Reports. 20: 100728. (IF3.385)

[18] Gui L, Lu W, Shi M, Hu R, Lu Y. (2020). Liver DNA methylation and transcriptome between 1- and 3-year-old grass carp. Aquaculture and Fisheries.

[19] Xie J#, Zhong Y#, Zhao Y, Xie W, Guo J, Gui L*, Li M* (2020). Characterization and expression analysis of gonad specific igf3 in the medaka ovary. Aquaculture and Fisheries.

[20] Pu Q#, Ma Y#, Zhong Y, Guo J, Gui L*, Li M*(2020). Characterization and expression analysis of sox3 in medaka gonads. Aquaculture and Fisheries.

[21] Xie Z#, Song P#, Zhong Y, Guo J, Gui L*, Li M*(2020). Medaka gcnf is a component of chromatoid body during spermiogenesis. Aquaculture and Fisheries.

[22] Sun B#, Gui L#, Liu R, Hong Y, Li M*(2020). Medaka oct4 is essential for gastrulation, central nervous system development and angiogenesis. Gene. 733:144270. (IF3.913)

[23] Sun L#, Zhong Y#, Qiu W, Guo J, Gui L*, Li M*(2020). MiR-26 regulates ddx3x expression in medaka (Oryzias latipes) gonads. Comparative Biochemistry and Physiology Part B. 246-247:110456. (IF2.495)

[24] Zhao Y#, Zhang Y#, Zhong Y, Guo J, Gui L*, Li M*(2020). Molecular identification and expression analysis of foxl2 and sox9b in Oryzias celebensis. Aquaculture and Fisheries.

[25] 赵雲, 桂朗*, 陈良标. 罗非鱼产业发展现状[J]. 中国水产, 2020(10).

[26] Zhou T. ^#, Gui L. ^#, Liu M., Li W., Hu P., Duarte D.F.C., Niu H., Chen L. (2019) Transcriptomic responses to low temperature stress in the Nile tilapia, Oreochromis niloticus. Fish Shellfish Immunol 84, 1145-56.

[27] Sun B^#, Gui L^#, Liu R, Hong Y, Li M^*. (2019). Medaka oct4 is essential for gastrulation, central nervous system development and angiogenesis. Gene. In press.

[28] Liang X^#, W J^#, Liu Y^#, Peng L, Li Y, Batista F, Power D, Gui L^*, Yang J^*. (2019). Complete genome of a marine bacterium Vibrio chagasii ECSMB14107 with the ability to infect mussels. Marine Genomics. 10.1016/j.margen.2019.04.008.

[29] Jian Wang, Yimeng Liu, Shouwen Jiang, Wenhao Li, Lang Gui, Tao Zhou, Wanying Zhai, Zixuan Lin, Jiaying Lu, Liangbiao Chen. (2019). Transcriptomic and epigenomic alterations of Nile tilapia gonads sexually reversed by high temperature. Aquaculture.

[30] Bi Q^#, Zhao Y^#, Du W^#, Lu Y, Gui L, Zheng Z, Yu H, Cui Y, Liu Z, Cui T, Cui D, Liu X, Li Y, Fan S, Hu X, Fu G, Ding J, Ruan C^*, Wang L^*. Pseudomolecule-level assembly of the Chinese oil tree yellowhorn (Xanthoceras sorbifolium) genome. GigaScience 2019, 8(6). (IF7.3)

[31] 桂朗, 张奇亚. (2019). 中国水产动物病毒学研究概述. 水产学报, 43, 168-87.

[32] Wang J, Liu Y, Jiang S, Li W, Gui L, Zhou T, Zhai W, Lin Z, Lu J, Chen L. (2019). Transcriptomic and epigenomic alterations of Nile tilapia gonads sexually reversed by high temperature. Aquaculture, 508: 167-177.

[33] Zhu,T. ^#, Gui,L. ^#, Zhu,Y., Li,Y., Li,M.(2018). Dnd is required for primordial germ cell specification in Oryzias celebensis. Gene,679,36-43.

[34] Gui,L., Li,T., Zhang,Q. (2018). Fish kidney cells show higher tolerance to hyperosmolality than amphibian. Aquaculture and Fisheries, 3, 135-138.

[35] Gui,L., Chinchar,V., Zhang,Q. (2018).Molecular basis of pathogenesis of emerging viruses infecting aquatic animals. Aquaculture and Fisheries, 3, 1-5.

[36] 廉颖,桂朗^*,张俊彬. (2018). 不同渗透压条件下金钱鱼肾原代细胞的差异蛋白分析[J].上海海洋大学学报, 27(06):855-863.

[37] Gui,L., Zhang,P., Zhang,Q., & Zhang,J. (2016). Two hepcidins from spotted scat (Scatophagus argus) possess antibacterial and antiviral functions in vitro. Fish & Shellfish Immunology,50,191-199.

[38] Gui,L., Zhang,P., Liang,X., Su,M., Wu,D., & Zhang,J. (2016). Adaptive responses to osmotic stress in kidney-derived cell lines from Scatophagus argus, a euryhaline fish. Gene, 583(2), 134.

[39] Wang,J. ^#, Gui,L. ^#, Chen,Z, & Zhang,Q. (2016). Mutations in the c-terminal region affect subcellular localization of Crucian carp herpesvirus (CaHV) GPCR. Virus Genes, 52(4), 484-494.

[40] Su, M., Mu, X., Gui, L., Zhang, P., Zhou, J., Ma, J., & Zhang, J. (2016). Dopamine regulates renal osmoregulation during hyposaline stress via drd1 in the spotted scat (Scatophagus argus). Sci Rep, 6, 37535.

[41] Su, M., Hu, P., Zhou, J., Ma, J., Li, S., Gui, L., & Zhang, J. (2016). Branchial transcriptional responses of spotted scat, Scatophagus argus, to acute hypo-osmotic stress. Agri Gene, 1, 100-108.

[42] Mu, X., Su, M., Gui, L., Liang, X., Zhang, P., Hu, P., Liu, Z., & Zhang, J. (2015). Comparative renal gene expression in response to abrupt hypoosmotic shock in spotted scat (Scatophagus argus). General & Comparative Endocrinology, 215, 25-35.

[43] Liu, H., Mu, X., Gui, L., Su, M., Li, H., Zhang, G., Liu, Z., & Zhang, J. (2015). Characterization and gonadal expression of foxl2 relative to cyp19a genes in spotted scat Scatophagus argus. Gene, 561(1), 6-14.

[44] Hu, P., Li, S., Zhong, Y., Mu, X., Gui, L., & Zhang, J. (2014). Identification of fxyd genes from the spotted scat (Scatophagus argus): molecular cloning, tissue-specific expression, and response to acute hyposaline stress. Comparative Biochemistry & Physiology Part B Biochemistry & Molecular Biology, 174(1), 15-22.

[45] Gui, L., Wang, B., Li, F. H., Sun, Y. M., Luo, Z., & Xiang, J. (2012). Blocking the large extracellular loop (LEL) domain of fc tetraspanin-3 could inhibit the infection of white spot syndrome virus (WSSV) in Chinese shrimp, Fenneropenaeus chinensis. Fish & Shellfish Immunology, 32(6), 1008-1015.

[46] 桂朗，王兵，王丽燕，李富花，相建海. (2012). 昆虫围食膜结构与功能概述及其对对虾WSSV病防治研究的启示，海洋科学，第36卷，第4期，126-131页.

[47] Wang, B., Li, F., Luan, W., Xie, Y., Zhang, C., Gui, L., Yan, H., Xiang, J., (2008). Comparison of gene expression profiles of Fenneropenaeus chinensis challenged with WSSV and Vibrio. Marine Biotechnology. 10(6):664-675.

[48] Zhou,G., Gui, L., Li, Z. Q., Yuan, X, & Zhang, Q. (2008). Generation and characterization of monoclonal antibodies against the flounder Paralichthys olivaceus rhabdovirus. Journal of Virological Methods, 148(1-2):205-210.

[49] Zhou, G, Gui, L., Li, Z, Yuan, X., & Zhang, Q. (2008). Establishment of a Chinese sturgeon (Acipenser sinensis) tail fin cell line and its susceptibility to frog iridovirus. Journal of Fish Biology. 73(8):2058-2067. 2008.

[50] 王兵，桂朗，李富花，相建海. (2008). 抑制性消减杂交技术结合cDNA MICROARRAY技术在中国明对虾WSSV感染后差异表达基因研究上的应用，海洋与湖沼，第39卷，第5期，455-461页.

[51] 桂朗，王兵，李富花，相建海. (2008). 四跨膜蛋白超家族Tetraspanin的免疫功能研究进展，生物化学与生物物理进展，第35卷，第11期，1231-1238页.

[52] 桂朗，李正秋，张奇亚. (2007).牙鲆一株弹状病毒病原的分离与鉴定，水生生物学报，第31卷，第3期，345-353页.

[53] Zhang, Q, Tao, J., Gui, L., Zhou, G., Ruan, H., Li, Z. & Gui, J. (2007). Isolation and characterization of Scophthalmus maximus rhabdovirus. Diseases of Aquatic Organisms. 74(2):95-105.

专著和教材情况

参编2018年在全球著名出版社Wiley-Blackwell出版发行的全英文水产巨著《Aquaculture in China: Success Stories and Modern Trends》，合作发表“Disease prevention and control 。

（Gui,L., Zhang,Q. (2018) 7.3. Disease prevention and control. Pp577-598. In Gui JF, Tang QS, Li ZJ, Liu JS, Sena SSDe (Eds). Aquaculture in China: Success Stories and Modern Trends. Wiley-Blackwell, Chichester, UK）

科教工作获奖情况

[1]水产与生命学院2022年度教职工人事考核优秀

[2]水产与生命学院2018年度教职工人事考核优秀

[3]2017年校级青年教师讲课比赛第二名

联系方式

地址：上海浦东沪城环路999号水产与生命学院

E-mail：lgui@shou.edu.cn

    本人每年招收硕士生多名，本人所在大团队可以招收博士生和博后。希望能够有致力水产动物抗病育种、鱼类干细胞操作技术的本科生、研究生或博士后加入本团队。本人的座右铭：机会只会眷顾做好准备的人。欢迎有志于在水产养殖专业中有所作为的青年学子们与本团队共同成长，实现人生价值与团队共赢。

2024年3月更新