邹钧，男，出生年月，1966年12月；籍贯，湖南；博士，特聘教授，博士生导师。水产动物生理与医学系。上海市高校水产动物免疫与疫病生态防控重点创新团队负责人。获国家自然科学基金委海外杰出青年基金资助、入选福建省上海市“高层次人才”、“闽江学者”、湖南省“百人计划”。2003-2017年任苏格兰鱼类研究中心科研主任，2018年受聘于上海海洋大学水产与生命学院。

任Fish and Shellfish Immunology主编、Aquaculture and Fisheries副主编、以及Developmental and Comparative Immunology、Comparative Immunology Reports、Biology-Basel、水产学报、水生生物学报、上海海洋大学和大连海洋大学学报编委；水产学会鱼病专业委员会副主任委员；水产学会水产动物免疫专业委员会委员；国际发育与比较免疫学会亚洲分会理事。

长期从事鱼类免疫学、病害防控和抗病育种研究。在Science China: Life Sciences、 Journal of Immunology、Journal of Virology、PLOS Pathogens等期刊发表SCI论文190余篇，参编1部研究生（副主编）教材、1部本科教材和3部英文编著，论文引用达12000余次。 

教育背景

1983-1987，北京大学、生物化学，理学学士；

1987-1990，中国科学院大学、鱼类遗传与育种，理学硕士；

1992-1998，University of Aberdeen、动物学，哲学博士 

教学工作情况

主讲研究生课程：Molecular Immunology（全英语）、比较免疫学、鱼类免疫学、水产动物医学前沿课程。 

主要研究方向

鱼类抗病的分子机制与抗病品系创制，鱼类疫苗与免疫制剂发掘与作用机理，宿主与病原互作机制，免疫系统的起源与演化。 

主持和参与的科教项目

[1] 科技部科技创新2030—重大项目，抗病抗逆鱼新品种设计与培育-抗出血病性状新种质创制课题，2023ZD0406502，2023-09至2025.12，主持。

[2] 国家自然科学基金区域创新发展联合重点项目，青鱼I型干扰素在抗病毒天然免疫中的机理研究，U21A20268, 2022-01至2025-12参与。

[3] 国家自然科学基金重点基金，草鱼CD4 T辅助（Th）细胞免疫系统及其应答病毒感染的分子机理研究，32030112，2021-01至2025-12，主持。

[4] 科技部重点研发计划“蓝色粮仓科技创新”重点专项“重要水产养殖生物抗病和抗逆性状的遗传基础与调控机制”-课题二“淡水鱼类抗病与抗逆性状形成的分子机理”-子课题，虹鳟传染性胰坏死病毒感染的分子基础，2018YFD0900302-4，2018-12至2022-12，主持。

[5] 上海市科委国际科技合作基金项目，19390743100，鱼类抗菌肽的挖掘与潜在产业应用，2019-11至2021-10，主持。

[6] 国家自然科学基金委员会，中国与葡萄牙科技基金会合作研究项目，41761134050，鱼类免疫在极端环境下的进化，2017-01至2019-12，参与。

[7] 国家自然科学基金国际重大合作项目，31320103913，鱼类伽马干扰素的分泌调控、信号传导及其免疫功能研究，2014-01至2018-12，参与。

[8] 国家自然科学基金海外杰出青年基金，30428024，RNAi转基因鱼，2005-01至2007-12，主持。

 近五年发表的主要论文

【1】 Zhang Y, Cen J, Yuan G, Jia Z, Chen K, Gao W, Chen J, Adamek M, Jia Z, Zou J*. DDX5 inhibits type I IFN production by promoting degradation of TBK1 and disrupting formation of TBK1 - TRAF3 complex. Cell Mol Life Sci. 2023; 80:212.

【2】 Yuan G, Zhao W, Zhang Y, Jia Z, Chen K, Wang J, Feng H, Zou J*. The biological functions and intestinal inflammation regulation of IL-21 in grass carp (Ctenopharyngodon idella) during infection with Aeromonas hydrophila. Cells. 2023;12(18):2276.

【3】 Zhao X, Ji N, Guo J, Huang W, Feng J, Shi Y, Chen K, Wang J, Zou J*. Zebrafish SETD3 mediated ubiquitination of phosphoprotein limits spring viremia of carp virus infection. Fish Shellfish Immunol. 2023; 1:108870.

【4】 Ji N, Huang W, Dang H, Xiao H, Shi Y, Guo J, Chen K, Wang J, Zou J*. CBFβ is induced by spring viremia of carp virus and promotes virus. Dev Comp Immunol. 2023; 147: 104751

【5】 Feng J, Jia Z, Yuan G, Zhu X, Liu Q, Wu K, Wang J, Zou J*. Expression and functional characterization of three β-defensins in grass carp (Ctenopharyngodon idella). Dev Comp Immunol. 2023; 140: 104616.

【6】 Wu K, Xu J, Jia Z, Wang J, Wang Z, Feng J, Zhu X, Liu Q, Wang B, Li M, Pang Y, Zou J*. Phylogeny and expression of ADAM10 and ADAM17 homologs in lamprey. Fish Physiol Biochem. 2023; 49(2):321-334.

【7】 Jia Z, Feng J, Dooley H, Zou J, Wang J. The first crystal structure of CD8αα from a cartilaginous fish. Front Immunol. 2023; 14:1156219.

【8】 Xiao H, Yun S, Huang W, Dang H, Jia Z, Chen K, Zhao X, Wu Y, Shi Y, Wang J, Zou J*. IL-4/13 expressing CD3γ/δ⁺ T cells regulate mucosal immunity in response to Flavobacterium columnare infection in grass carp. Fish Shellfish Immunol. 2023; 134: 108586.

【9】 Shi Y, Chen K, Zhao X, Lu Y, Huang W, Guo J, Ji N, Jia Z, Xiao H, Dang H, Zou J*, Wang J*. IL-27 suppresses spring viremia of carp virus replication in zebrafish. Fish Shellfish Immunol. 2023; 133: 108530.

【10】 Guo J, Huang W, Zhao X, Ji N, Chen K, Shi Y, Feng J, Zou J*, Wang J*. The expanded ISG12 family in zebrafish: ISG12.1 suppresses virus replication via targeting viral phosphoprotein. Dev Comp Immunol. 2023; 142: 104672.

【11】 Jia Z, Feng J, Yuan G, Xiao H, Dang H, Zhang Y, Chen K, Zou J, Wang J. The Meteorin-like cytokine is upregulated in grass carp after infection with Aeromonas hydrophila. Dev Comp Immunol. 2023; 141: 104632.

【12】 Chen K, Xiu Q, Min Q, Cheng X, Xiao H, Jia Z, Feng J, Shi Y, Zhuo Q, Wang J, Zou J*. TL1A induces apoptosis via DR3 in grass carp (Ctenopharyngodon idella). Fish and Shellfish Immunology Reports. 2023; 100090.

【13】 Huang W, Zhao X, Ji N, Guo J, Feng J, Chen K, Wu Y, Wang J, Feng H, Zou J*. IRF2 cooperates with phosphoprotein of spring viremia of carp virus to suppress antiviral response in zebrafish. J Virol. 2022; 96(22): e0131422.

【14】 Zhu X, Wang J, Jia Z, Feng J, Wang B, Wang Z, Liu Q, Wu K, Huang W, Zhao X, Dang H, Zou J*. Novel dimeric architecture of an IFN-γ-related cytokine provides insights into subfunctionalization of type II IFNs in teleost fish. J Immunol. 2022; 209(11): 2203-2214.

【15】 Wang Z^#, Xu J^#, Feng J, Wu K, Chen K, Jia Z, Zhu X, Huang W, Zhao X, Liu Q, Wang B, Chen X, Wang J, Zou J*. Structural and functional analyses of type I IFNa shed light into its interaction with multiple receptors in fish. Front Immunol. 2022; 13: 862764.

【16】 Zhao X, Huang W, Shi Y, Guo J, Xiao H, Ji N, Feng J, Dang H, Zou J*. PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish. Front Immunol. 2022 12; 13: 979919.

【17】 Zhao X^#, Huang W^#, Guo J, Ji N, Feng J, Shi Y, Chen K, Zou J*. PLAAT1 promotes p53 degradation via autophagy-lysosome pathway in zebrafish. Fish Shellfish Immunol. 2022; 125: 48-53.

【18】 Dang H, Hassan Z, Jia Z, Wu Y, Xiao H, Huang W, Guo X, Zhao X, Li Y, Zou J, Wang J. Grass carp IL-20 binds to IL-20R2 but induces STAT3 phosphorylation via IL-20R1. Fish Shellfish Immunol. 2023; 132: 108445.

【19】 Wang J, Jia Z, Dang H, Zou J*. Meteorin-like/Meteorin-beta upregulates proinflammatory cytokines via NF-kappaB pathway in grass carp Ctenopharyngodon idella. Dev Comp Immunol. 2022; 127: 104289.

【20】 Wu Y, Jia Zhao, Dang H, Xiao H, Huang W, Liu Q, Chen K, Zhang L, Zou J* and Wang J*. Molecular characterization, evolution and expression analysis of TNFSF14 and three TNFSF receptors in Spotted Gar Lepisosteus oculatus. Journal of Marine Science and Engineering. 2022; 10: 1035.

【21】 Wang B, Qin Y, Sun Z, Zhu X, Jia Z, Chen K, Liu D, Wang J, Zou J*. Production and characterization of monoclonal antibodies against grass carp CD4-1 and CD4-2. Aquaculture and Fisheries. 2022;https://doi.org/10.1016/j.aaf.2022.02.009.

【22】 Huang W, Ji N, Zhao X, Guo J, Feng J, Chen K, Wu Y, Wang J, Zou J*. RNA-seq analysis of a zebrafish caudal fin cell line in response to infection with spring viraemia of carp virus. Aquaculture and Fisheries. 2022.

【23】 Lu Y, Li W, Li Y, Zhai W, Zhou X, Wu Z, Jiang S, Liu T, Wang H, Hu R, Zhou Y, Zou J, Hu P, Guan G, Xu Q, Canário AVM, Chen L. Population genomics of an icefish reveals mechanisms of glacier-driven adaptive radiation in Antarctic notothenioids. BMC Biol. 2022; 20(1): 231.

【24】 Chen J, Guan Y, Guan H, Mu Y, Ding Y, Zou J, Ouyang S, Chen X. Molecular and structural basis of receptor binding and signaling of a fish type I IFN with three disulfide bonds. J Immunol. 2022; 209(4): 806-819.

【25】 Wang Q, Ai Y, Wang C, Liu Y, Zhong H, Yan W, He Y, Deng Z, Zou J, Feng H. PKACα negatively regulates TAK1/IRF7 signaling in black carp Mylopharyngodon piceus. Dev Comp Immunol. 2022; 127: 104306.

【26】 Wang J, Wang W, Xu J, Jia Z, Liu Q, Zhu X, Xia C*, Zou J*. Structural insights into the co-evolution of IL-2 and its private receptor in fish. Dev Comp Immunol. 2021; 115: 103895.

【27】 Wu Y, Yang Y, Dang H, Xiao H, Huang W, Jia Z, Zhao X, Chen K, Ji N, Guo J, Qin Z, Wang J, Zou J*. Molecular identification of Klebsiella pneumoniae and expression of immune genes in infected spotted gar Lepisosteus oculatus. Fish Shellfish Immunol. 2021; 119: 220-230.

【28】 Wei W, Wang J, Min Q, Jia Z, Chen K, Feng H, Zou J*. CCL19 variants mediate chemotactic response via CCR7 in grass carp Ctenopharyngodon idella. Dev Comp Immunol. 2021; 122: 104127.

【29】 Hassan Z, Wang J, Qin Y, Wang W, Liu Q, Lei L, Sun Z, Yang Y, Wu K, Zhu X, Wang Z, Feng H, Zou J*. Functional characterization of an interleukin 20 like homologue in grass carp Ctenopharyngodon idella. Fish Shellfish Immunol. 2021; 115: 43-57.

【30】 Chen K, Tian J, Wang J, Jia Z, Zhang Q, Huang W, Zhao X, Gao Z, Gao Q, Zou J*. Lipopolysaccharide-induced TNFalpha factor (LITAF) promotes inflammatory responses and activates apoptosis in zebrafish Danio rerio. Gene. 2021; 780: 145487.

【31】 Sun Z, Qin Y, Liu D, Wang B, Jia Z, Wang J, Gao Q, Zou J*, Pang Y*. The evolution and functional characterization of CXC chemokines and receptors in lamprey. Dev Comp Immunol. 2021; 116: 103905.

【32】 Jia Z, Wang J, Chen K, Zhang Q, Sun Z, Hassan Z, Feng H, Zou J*. Identification and expression analysis of group II C-type lectin domain containing receptors in grass carp Ctenopharyngodon idella. Gene. 2021; 789: 145668.

【33】 Peng F, Jin S, Chen Z, Chang H, Xiao J, Li J, Zou J, Feng H. TRIF-mediated antiviral signaling is differentially regulated by TRAF2 and TRAF6 in black carp. Dev Comp Immunol. 2021; 121: 104073.

【34】 Adamek M, Davies J, Beck A, Jordan L, Becker AM, Mojzesz M, Rakus K, Rumiac T, Collet B, Brogden G, Way K, Bergmann SM, Zou J, Steinhagen D. Antiviral actions of 25-hydroxycholesterol in fish vary with the virus-host combination. Front Immunol. 2021; 12: 581786.

【35】 Qin Y, Sun Z, Wang W, Xu J, Wang B, Jia Z, Li X, Wang J, Gao Q, Chen X, Zou J*. Characterization of CD3gamma/delta (+) cells in grass carp (Ctenopharyngodon idella). Dev Comp Immunol. 2021; 114: 103791.

【36】 Li Y, Xiao T*, Zou J*. Fish TNF and TNF receptors. Sci China Life Sci. 2021; 64(2): 196-220.

【37】 Xu J, Wang J, Min Q, Wang W, Qin Y, Lei L, Gao Q, Zou J*. Characterisation of IL-21 and IL-21Rα in grass carp: IL-21-producing cells are upregulated during Flavobacterium columnare infection. Aquaculture and Fisheries. 2021.

【38】 Dai Y, Cao Y, Chen Z, Huang J, Xiao J, Zou J, Feng H. RIPK3 collaborates with RIPK1 to inhibit MAVS-mediated signaling during black carp antiviral innate immunity. Fish Shellfish Immunol. 2021; 115: 142-149.

【39】 Cao Y, Chen Z, Huang J, Wu H, Zou J, Feng H. Black carp TUFM collaborates with NLRX1 to inhibit MAVS-mediated antiviral signaling pathway. Dev Comp Immunol. 2021; 122: 104134.

【40】 Peng F, Jin S, Chen Z, Chang H, Xiao J, Li J, Zou J, Feng H. TRIF-mediated antiviral signaling is differentially regulated by TRAF2 and TRAF6 in black carp. Dev Comp Immunol. 2021; 121: 104073.

【41】 Yang Y, Wang J, Xu J, Liu Q, Wang Z, Zhu X, Ai X, Gao Q, Chen X, Zou J*. Characterization of IL-22 Bioactivity and IL-22-Positive Cells in Grass Carp Ctenopharyngodon idella. Front Immunol. 2020; 11: 586889.

【42】 Wang W, W ang J, Lei L, Xu J, Qin Y, Gao Q, Zou J*. Characterisation of IL-15 and IL-2Rbeta in grass carp: IL-15 upregulates cytokines and transcription factors of type 1 immune response and NK cell activation. Fish Shellfish Immunol. 2020; 107(Pt A): 104-17.

【43】 Cheng X, Jiang X, Song Y, Gao J, Xue Y, Hassan Z, Gao Q*, Zou J*. Identification and modulation of expression of a TNF receptor superfamily member 25 homologue in grass carp (Ctenopharyngodon idella). Aquaculture and Fisheries. 2020; 5: 28-35.

【44】 Jiang X, Wang J, Wana S, Xue Y, Sun Z, Cheng X, Gao Q*, Zou J*. Distinct expression profiles and overlapping functions of IL-4/13A and IL-4/13B in grass carp (Ctenopharyngodon idella). Aquaculture and Fisheries. 2020; 5: 72-79.

【45】 Liu F, Wang T, Petit J, Forlenza M, Chen X, Chen L, Zou J, Secombes CJ. Evolution of IFN subgroups in bony fish - 2. analysis of subgroup appearance and expansion in teleost fish with a focus on salmonids. Fish Shellfish Immunol. 2020; 98: 564-573.

【46】 Gan Z^#, Chen S^#, Huang B, Zou J, Nie P. Fish type I and type II interferons: composition, receptor usage, production and function. Reviews in Aquaculture. 2020; 12: 773-804.

【47】 Li X, Yuan S, Sun Z, Lei L, Wan S, Wang J, Zou J, Gao Q. Gene identification and functional analysis of peptidoglycan recognition protein from the spotted sea bass (Lateolabrax maculatus). Fish Shellfish Immunol. 2020; 106: 1014-1024.

【48】 Zhao X, Xiao T, Jin S, Wang J, Wang J, Luo H, Li R, Sun T, Zou J, Li Y. Characterization and immune function of the interferon-β promoter stimulator-1 in the barbel chub, Squaliobarbus curriculus. Dev Comp Immunol. 2020; 104: 103571.

【49】 Liu F, Bols NC, Pham PH, Secombes CJ, Zou J*. Evolution of IFN subgroups in bony fish - 1: Group I-III IFN exist in early ray-finned fish, with group II IFN subgroups present in the Holostean spotted gar, Lepisosteus oculatus. Fish Shellfish Immunol. 2019; 95: 163-170.

【50】 Zhang C, Zhang Q, Wang J, Tian J, Song Y, Xie H, Chang M, Nie P, Gao Q*, Zou J*. Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish. Fish Shellfish Immunol. 2019; 94: 685-696.

【51】 Xue Y, Jiang X, Gao J, Li X, Xu J, Wang J, Gao Q*, Zou J*. Functional characterisation of interleukin 34 in grass carp Ctenopharyngodon idella. Fish Shellfish Immunol. 2019; 92: 91-100.

【52】 Gao J, Jiang X, Wang J, Xue Y, Li X, Sun Z, Xie H, Nie P, Zou J*, Gao Q*. Phylogeny and expression modulation of interleukin 1 receptors in grass carp (Ctenopharyngodon idella). Dev Comp Immunol. 2019; 99:103401.

【53】 Jiang X, Gao J, Xue Y, Qin Y, Li X, Sun Z, Xie H, Chang M, Nie P, Zou J*, Gao Q*. Identification and expression analysis of IL-4/13 receptors in grass carp. Ctenopharyngodon idella. Fish Shellfish Immunol. 2019; 87: 254-264.

【54】 Song Y, Cheng X, Jiang X, Gao J, Xue Y, Tian J, Zhang C, Wang S, Zhou J, Zou J, Qi Z, Gao Q. Identification and expression analysis of suppressors of cytokine signaling (SOCS) from soiny mullet (Liza haematocheila). Fish Shellfish Immunol. 2019; 90: 102-108.

【55】 Dehler CE, Lester K, Della Pelle G, Jouneau L, Houel A, Collins C, Dovgan T, Machat R, Zou J, Boudinot P, Martin SAM, Collet B. Viral Resistance and IFN Signaling in STAT2 Knockout Fish Cells. J Immunol. 2019; 203(2): 465-475.

【56】 Redmond AK, Zou J, Secombes CJ, Macqueen DJ, Dooley H. Discovery of All Three Types in Cartilaginous Fishes Enables Phylogenetic Resolution of the Origins and Evolution of Interferons. Front Immunol. 2019; 10: 1558.

【57】 Milne DJ, Fernández-Montero A, Gundappa MK, Wang T, Acosta F, Torrecillas S, Montero D, Zou J, Sweetman J, Secombes CJ. An insight into piscidins: The discovery, modulation and bioactivity of greater amberjack, Seriola dumerili, piscidin. Mol Immunol. 2019; 114: 378-388.

 申请和授权专利情况

【1】 邹钧，季宁，王俊亚，黄文吉，分泌抗传染性胰腺坏死病毒VP2单克隆抗体的杂交瘤细胞株、单克隆抗体和应用。发明专利号申请号：202211039158.0。

【2】 邹钧，张艳维，高谦，王俊亚，覃钰婷，王邦杰，草鱼CD3e杂交瘤细胞株及单克隆抗体和应用。发明专利号申请号：202211038897.8。

专著和教材

【1】 《水产动物免疫学》研究生教材，科学出版社，2023，副主编。

【2】 《水产动物免疫学》本科教材，农业出版社，2021，参编。

【3】 《The evolution of the Immune System: Conservation and Diversification》，Academic Press，2016，《The evolution of the Immune System: Conservation and Diversification》，Academic Press，2016，参编。

【4】 《Immunobiology of the Shark》，CRC Press Taylors & Francis Group，2015，参编。

【5】 《Fish Defenses, Vol 1: Immunology》，Science Publishers，2009，参编。

联系方式

地址：上海市浦东新区沪城环路999号

E-mail：jzou@shou.edu.cn