1. 个人基本情况：

陈良标，男，上海海洋大学教授，博士生导师，中科院百人计划，国家杰出青年基金获得者，入选“国家百千万人才工程”，享受国务院特殊津贴。现担任海洋生物科学国际联合研究中心主任，先后主持科技部重点研发计划、国家基金委重点、面上等国家级项目10多项， 在Nature，Nature Communications，PNAS，Nucleic Acids Research，BMC Biology，Gigascience，Molecular Biology and Evolution，Stem Cell and Development 等领域重要杂志发表了一系列论文，在鱼类的适应性进化方面取得了重要成果。获得教育部高等学校科学研究优秀成果一等奖，海洋科学技术一等奖等奖励。担任中国水产学会水产生物技术与遗传育种专业委员会副主任委员，Zoological Research、Aquaculture and Fisheries、上海海洋大学学报、大连海洋大学学报等期刊编委。培养毕业的博士生中多人入选国家和地方人才计划。

陈良标博士领导的创新小组的主要研究方向是动物进化与环境基因组学。主要通过高通量的基因组测序，分子生物学，生物信息学和细胞生物学等研究手段，阐述新基因起源的分子和进化机制, 鱼类环境适应的分子机制，基因组进化与环境的相互关系。目前实验室的研究方向有：

[1]极地鱼类适应极端环境的遗传与发育生物学机制；

[2]鱼类比较基因组学和分子进化；

[3]鱼类抗逆基因的挖掘和利用；

[4]生物信息学。

2. 教育经历：

1991年8月至1996年12月，伊利诺伊大学香槟分校，分子与整合生理学，博士；

1988年9月至1991年7月，中国科学院发育生物学研究所，发育生物学，硕士；

1984年9月至1988年7月，杭州大学，生物系，学士

3. 工作经历：

2013年1月至今，上海海洋大学，教授；

2003年至2012年，中国科学院遗传与发育生物学研究所，研究员；

2001年至2002年，浙江大学，教授；

2000年至2001年，美国Doubletwist Inc.（USA），工程师；

1997年至1999年，美国National Institutes of Health，博士后

4. 主持的科研项目：

[1]国家重点研发计划项目：耐高温大口黑鲈和抗链球菌病罗非鱼新品种培育，2022-2026，2022YFD2400800，2000万元

[2]国家自然科学基金重点项目：耐寒河鲀品种的耐寒主效基因挖掘和应用研究制研究，2022-2026，32130109，283万元

[3]国家重点研发计划项目：重要养殖生物对典型环境胁迫的响应机制和生理生态效应研究，2018-2022，2018YFD0900600，3617万元

[4]上海市科委“一带一路”国际联合实验室项目：海洋生物科学国际联合实验室，2019-2022，19590750500，300万元（含配套经费）

[5]国家自然基金委国际（地区）合作与交流项目：鱼类免疫在极端环境下的进化，2017-2019，41761134050，直接经费251万元

[6]国家自然基金委面上项目：抗冻蛋白基因LD4提高鱼类抗寒性能的分子机制研究，2016-2019，31572611，直接经费65万元

[7]上海市教委研创新计划项目：以南极亚目鱼类为对象研究环境因子与基因组进化的相互作用及机制，2017-2022，2017-01-07-00-10-E00060，300万元

[8]国家自然基金委重点项目：青藏高原裂腹鱼类的分子进化和高原适应的机制研究，2012－2016，31130049，333万元

[9]国家重点研发计划课题：鱼类抗寒基因调控网络和分子设计育种的基础研究，2010－2014, 2010CB126304，317万元

[10]国家自然基金委重大国际（地区）合作交流项目：南极持续寒冷环境下鱼类蛋白质组的适应性进化研究，2011－2013，30910103906，110万元

[11]农业部转基因重大专项：耐寒基因克隆和功能验证新技术的研究，2009－2012，2009ZX08009-003B，304万元

[12]国家自然基金委杰出青年项目：动物进化和动物遗传学，2007-2010，30625007，200万元

5. 代表性论文：

[1] Jigang Lu^#, Siqi Huang^#, Shicen Wei^#, Jiangbo Cheng, Wei Li, Yueyue Fei, Jihui Yang , Ruiqin Hu, Songqian Huang, Wanying Zhai, Zhichao Wu, Mingli Liu, Qianghua Xu, Peng Hu*, Liangbiao Chen^*. (2025) Heat inducible nuclear translocation of Kdm6bb drives temperature dependent sex reversal in Nile tilapia. PLOS Genetics. (Accept) https://doi.org/10.1371/journal.pgen.1011664

[2] Wenyi Yang^#, Mingjian Peng^#, Youquan Wang, Xiaowen Zhang, Wei Li, Xue Zhai, Zhichao Wu, Peng Hu*, Liangbiao Chen. (2025) Deletion of Hepcidin Disrupts Iron Homeostasis and Hematopoiesis in Zebrafish Embryogenesis. Development. 152, 7

[3] He Jiao^#, Songqian Huang^#, Minghao Zhang, Qiao Huang, Chenyu Yan, Jingting Qi, Jiangbo Cheng, Yuan Xu, Xue Zhai, Xinwen Li, Siyao Zhan, Wei Li, Zhichao Wu, Jiulin Chan, Liangbiao Chen^*, Peng Hu*. (2025) Uncovering the Chromatin-Mediated Transcriptional Regulatory Network Governing Cold Stress Responses in Fish Immune Cells. Journal of Genetics and Genomics. (In Press) https://doi.org/10.1016/j.jgg.2025.01.008

[4] Shuang Han^#, Jie Wang^#, Jingping Zhang, Youquan Wang, Yuhao Luo, Qigen Liu, Liangbiao Chen^*. (2025) Gwas and Selective Sweep Analysis Reveal the Genetic Basis of Cold Tolerance in the Domesticated Pufferfish (Takifugu Obscurus). Aquaculture. 598: 742018.

[5] Wang Jie^#, Shuang Han^#, Yuhao Luo, Jingping Zhang, Youquan Wang, Liangbiao Chen^*. (2025) Comparative Transcriptomic Analysis Reveals the Gut-Brain Axis Regulatory Mechanisms in Cold-Tolerant Pufferfish (Takifugu Fasciatus) under Cold Stress. Aquaculture. 598: 742033.

[6] Qianghua Xu*, Ruonan Jia, Fei Yang, Peng Hu, Xue Li, Saiya Ge, Shouwen Jiang, Jiulin Chan, Wanying Zhai, Liangbiao Chen^*. (2024) Identification of two miRNAs regulating cardiomyocyte proliferation in an Antarctic icefish. iScience. 27, 110128

[7] Ruiqin Hu, Genfang Li, Peng Hu, Hongbo Niu, Wenhao Li, Shouwen Jiang, Guijun Guan, Qianghua Xu, Mingli Liu, Liangbiao Chen^*. (2024) Bmp10 Maintains Cardiac Function by Regulating Iron Homeostasis. Journal of Genetics and Genomics. 51(12): 1459-1473.

[8] Wenhao Li^#, Jie Song^#, Huaming Tu^#, Shouwen Jiang, Binbin Pan, Jiazhen Li, Yongpeng Zhao, Liangbiao Chen^*, Qianghua Xu. (2024) Genome sequencing of Coryphaenoides yaquinae reveals convergent and lineage‐specific molecular evolution in deep‐sea adaptation. Mol. Ecol. Resour. 24, e13989

[9] Wen Hao Li^#, Zhi Qiang Li^#, Meng Di Bu^#, Jia Zhen Li, Liangbiao Chen^*. (2024) Metabolomic-Based Analysis Reveals Bile Acid-Mediated Ovarian Failure Induced by Low Temperature in Zebrafish. Zoological Research 45(4): 791.

[10] Wang Jie^#, Jingping Zhang^#, Shuang Han, Youquan Wang, Liangbiao Chen^*. (2024) Establishment and Characterization of a Fin Cell Line from Takifugu Obscurus and Its Application to Fish Immunology. Journal of Fish Biology. https:// doi.org/10.1111/jfb.16021

[11] Jie Wang^#, Shuang Han^#, Jingping Zhang, Yuhao Luo, Youquan Wang, and Liangbiao Chen^*. (2024) Establishment and Characterization of a Gill Cell Line from Takifugu Obscurus and Transcriptome Analysis of Its Gene Expression Profiles Upon Low Temperature. Fish & Shellfish Immunology. 153: 109843.

[12] Minghui Niu, Huamin Wang, Zhichao Wu, Shouwen Jiang, Liangbiao Chen^*. (2024) Deletion of Asb15b Gene Can Lead to a Significant Decrease in Zebrafish Intermuscular Bone. Gene. 923: 148561.

[13] Xiaoting Gong, Qianqian Yan, Liangbiao Chen^*. (2024) Transient Receptor Potential A1b Regulates Primordial Germ Cell Numbers and Sex Differentiation in Developing Zebrafish. Journal of Fish Biology. https://doi.org/10.1111/jfb.16005

[14] Ying Wang, Hua Min Wang, Yan Zhou, Ling Hong Hu, Jing Ming Wan, Ji Hui Yang, Hong Bo Niu, Xiu Ping Hong, Peng Hu, Liangbiao Chen^*. (2023) Dusp1 regulates thermal tolerance limits in zebrafish by maintaining mitochondrial integrity. Zoological Research. 44(1):126-141.

[15] Wanying Zhai^#, Wang Qian^#, Zhu Xinpeng, Jia Xiaoying, Liangbiao Chen^* (2023) Pathogenic infection and microbial composition of yellow catfish (Pelteobagrus fulvidraco) challenged by Aeromonas veronii and Proteus mirabilis. Aquaculture and Fisheries. 8(2): 166-173

[16] Xin Zhang, Zhichao Wu, Mengdi Bu, Ruiqin Hu, Xiaowen Zhang, Wenhao Li, Liangbiao Chen^*. (2023) The CCAAT/Enhancer Binding Protein Beta (cebpb) is essential for the development of enveloping layer (EVL) in zebrafish. Aquaculture and Fisheries. 8(3): 252-260

[17] Ying Lu^#, Wenhao Li^#, Yalin Li^#, Wanying Zhai^#, Xuming Zhou^#, Zhichao Wu, Shouwen Jiang, Taigang Liu, Huamin Wang, Ruiqin Hu, Yan Zhou, Jun Zou, Peng Hu, Guijun Guan, Qianghua Xu^*, Adelino V.M. Canário^*, Liangbiao Chen*. (2022) Population genomics of an icefish reveals mechanisms of glacier-driven adaptive radiation in Antarctic Notothenioid. BMC Biology. 20: 231.

[18] Ruiqin Hu, Yanna Xu, Bingshe Han, Yi Chen, Wenhao Li, Guijun Guan, Peng Hu, Yan Zhou, Qianghua Xu, Liangbiao Chen*. (2022) MiR-202-3p determines embryo viability during mid-blastula transition. Front. Cell Dev. Biol. 10:897826.

[19] Yan Zhou, Yanjie Zhang, Shang Wei, Wei Li, Wenhao Li, Zhichao Wu, Shouwen Jiang, Ying Lu, Qianghua Xu, Liangbiao Chen*. (2022) Reduced Hypoxia Tolerance and Altered Gill Morphology at Elevated Temperatures May Limit the Survival of Tilapia (GIFT, Oreochromis niloticus) under Global Warming. Fishes, 7, 216.

[20] Shuang Han, Shang Wei, Ruoyu Chen, Man Ni, Liangbiao Chen*. (2022) Tissue-Specific and Differential Cold Responses in the Domesticated Cold Tolerant Fugu. Fishes, 7, 159.

[21] Huamin Wang, Ying Wang, Minghui Niu, Linghong Hu, Liangbiao Chen^*. (2022) Cold Acclimation for Enhancing the Cold Tolerance of Zebrafish Cells. Front Physiol.12:813451.

[22] Mingli Liu, Ruiqin Hu , Wenhao Li , Wenyi Yang , Qianghua Xu , Liangbiao Chen^*. (2022) Identification of Antibacterial Activity of Hepcidin From Antarctic Notothenioid Fish. Front Microbiol.13:834477.

[23] Qiao Huang^#, Ruiqin Hu^#, Hui zhu, Changlian Peng*, Liangbiao Chen*. (2021) The cold resistant activities of multi-domain type III antifreeze proteins from Antarctic eelpout Lycodichths dearborni revealed by transgenic tobaccos, Aquaculture and Fisheries, 6(2): 186-191.

[24] Jigang Lu, Wei Li, Ruiqin Hu, Yan Zhou, Yueyue Fei, Yanjie Zhang, Wanying Zhai, Liangbiao Chen^*. (2021) Molecular and morphological changes in Nile tilapia (Oreochromis niloticus) gonads during high-temperature-induced masculinization. Aquaculture Research.53 (3): 921-931.

[25] Ying Wang, Huamin Wang, Linghong Hu, Liangbiao Chen*. (2021) Leptin Gene Protects Against Cold Stress in Antarctic Toothfish. Front Physiol.12:740806.

[26] Xinting Zhang^#, Yuyang Chang^#, Wanying Zhai^#, Feng Qian, Yingqing Zhang, Shumei Xu, Haiyan Guo, Siyu Wang, Ruiqin Hu, Xiaozhu Zhong, Xiaomiao Zhao, Liangbiao Chen*, Guijun Guan*（2020） A potential role for the Gsdf-eEF1α complex in inhibiting germ cell proliferation: A protein-interaction analysis in medaka (Oryzias latipes) from a proteomics perspective. Mol Cell Proteomics. 20, 10023, 1-13

[27] Liangbiao Chen^#, Ying Lu^#, Wenhao Li^#, Yandong Ren, Mengchao Yu, Shouwen Jiang, Yanxia Fu, Jian Wang, Sihua Peng, Kevin T. Bilyk, Katherine R. Murphy, Xuan Zhuang, Mathias Hune; Wanying Zhai, Wen Wang, Qianghua Xu*, Chi-Hing Christina Cheng*. (2019) Genomic bases for colonizing the freezing Southern Ocean revealed by the genomes of Antarctic toothfish and Patagonia robalo. GigaScience. 8, 1-16

[28] Jian Wang^#, Yimeng Liu^#, Shouwen Jiang, Wenhao Li, Lang Gui, Tao Zhou, Wanying Zhai, Zixuan Lin, Jiaying Lu, and Liangbiao Chen^*. (2019) Transcriptomic and epigenomic alterations of Nile tilapia gonads sexually reversed by high temperature. Aquaculture. 508:167-177.

[29] Tao Zhou^#, Lang Gui^#, Mingli Liu, Wenhao Li, Peng Hu, Daniel F.C. Duarte, Hongbo Niu and Liangbiao Chen*. (2019) Transcriptomic responses to low temperature stress in the Nile tilapia, Oreochromis niloticus. Fish Shellfish Immunology 84:1145-1156.

[30] Rizka Rahmana Putri , Liangbiao Chen* (2018) Spatiotemporal control of zebrafish ( Danio rerio ) gene expression using a light-activated CRISPR activation system. Gene. 677: 273-279.

[31] Dongsheng Zhang^#, Mengchao Yu^#, Peng Hu^#, Sihua Peng, Yimeng Liu, Weiwen Li, Congcong Wang, Shunping He, Wanying Zhai, Qianghua Xu, Liangbiao Chen*. (2017) Genetic Adaptation of the Schizothoracine Fishes to the Phased Uplifting of Qinghai-Tibetan Plateau. G3: Genes, Genomes, Genetics. 7 (4): 1267-1276

[32] Mengchao Yu^#, Dongsheng Zhang^#, Peng Hu, Sihua Peng, Wenhao Li, Shunping He, Wanying Zhai, Qianghua Xu*, Liangbiao Chen*. (2017) Divergent adaptation to Qinghai-Tibetan Plateau implicated from transciptome study of Gymnocypris dobula and Schizothorax nukiangensis. Biochemical Systematics and Ecology. 71:97-105.

[33] Lixue Cao^#, Qiao Huang^#, Zhichao Wu^#, Dong-dong Cao^#, Zhanling Ma^#, Qianghua Xu, Peng Hu, Yanxia Fu, Yu Shen, Jiulin Chan, Cong-zhao Zhou, Wanying Zhai, Liangbiao Chen*. (2016) Neofunctionalization of zona pellucida proteins enhances freeze-prevention in the eggs of Antarctic notothenioids. Nature Communications. 7: 12987

[34] Peng Hu, Mingli Liu, Yimeng Liu, Jinfeng Wang, Dong Zhang, Hongbo Niu, Shouwen Jiang, Jian Wang, Dongsheng Zhang, Bingshe Han, Qianghua Xu and Liangbiao Chen*.(2016) Transcriptome comparison reveals a genetic network regulating the lower temperature limit in fish. Scientific Reports. 6:28952

[35] Qianghua Xu*, Chi Zhang, Dongsheng Zhang, Huapeng Jiang, Sihua Peng, Yang Liu, Kai Zhao, Congcong Wang, Liangbiao Chen*. (2016) Analysis of the erythropoietin of a Tibetan Plateau schizothoracine fish (Gymnocypris dobula) reveals enhanced cytoprotection function in hypoxic environments. BMC Evolutionary Biology. 16 (1): 11

[36] Peng Hu, Mingli Liu, Dong Zhang, Jinfeng Wang, Hongbo Niu, Yimeng Liu, Zhichao Wu, Bingshe Han, Wanying Zhai, Yu Shen, Liangbiao Chen*. (2015) Global identification of the genetic networks and cis-regulatory elements of the cold response in zebrafish, Nucl. Acids Res. 43 (19): 9198-9213.

[37] Qianghua Xu*, Chang Cai, Xingxing Hu, Yun Liu, Yanan Guo, Peng Hu, Zuozhou Chen, Sihua Peng, Dongsheng Zhang, Shouwen Jiang, Zhichao Wu, Jiulin Chan, Liangbiao Chen*. (2015) Evolutionary suppression of erythropoiesis via the modulation of TGF-β signalling in an Antarctic icefish. Molecular Ecology. 24(18): 4664-4678.

[38] Shengjian Huang, Ming Cai, Yinghui Zheng, Longhai Zhou, Qiang Wang, Liangbiao Chen*. (2014) miR-888 in MCF-7 side population sphere cells directly targets E-cadherin. Journal of Genetics and Genomics. 41(1): 35-42.

[39] Qianghua Xu^#, Guang Li^#, Lixue Cao, Zhongjun Wang, Hua Ye, Xiaoyin Chen, Xi Yang, Yiquan Wang, and Liangbiao Chen*. (2012) Proteomic characterization and evolutionary analyses of zonapellucida domain-containing proteins in the egg coat of the cephalochordate, Branchiostomabelcheri. BMC Evolutionary Biology. 12 (1): 239

[40] Bin Gu^#, Jiarong Zhang^#, Shihao Wang, Xiuli Song, Cheng Xu, Liangbiao Chen*, and Zhang Ming*. (2012) Aire promotes the self-renewal of embryonic stem cells through Lin28. Stem Cells and Development. 21: 2878-2890.

[41] Yang Na, Peng Changlian, Cheng Deng, Huang Qiao, Xu Guanghui, Gao Fei, Chen Liangbiao*. (2012) The over-expression of calmodulin from Antarctic notothenioid fish increases cold tolerance in tobacco. Gene, 521(1):32–37

[42] Ruolin Yang^#, Zhonghua Dai^#, Shue Chen, and Liangbiao Chen*. (2011) MicroRNA-mediated gene regulation plays a minor role in the transcriptomic plasticity of cold-acclimated zebrafish brain tissue. BMC Genomics. 12:605.

[43] Cheng Deng^#, C-H Christina Cheng, Hua Ye, Ximiao He, Liangbiao Chen*. (2010) Evolution of an antifreeze protein by neofunctionalization under escape from adaptive conflict. Proc. Natl. Acad. Sci. USA. 107(50):21593-21598.

[44] Zhonghua Dai^#, Zuozhou Chen^#, Hua Ye, Longhai Zhou, and Liangbiao Chen*. (2009) Characterization of microRNAs in cephalochordates reveals a correlation between miRNA repertoire homology and morphological similarity in chordate evolution. Evolution and Development. 11(1) 41-49.

[45] Chang-Qing Xie , Huarong Huang, Sheng Wei, Long-Sheng Song, Jifeng Zhang, Raquel P Ritchie, Liangbiao Chen, Ming Zhang, Y Eugene Chen (2009) A Comparison of Murine Smooth Muscle Cells Generated from Embryonic versus Induced Pluripotent Stem Cells. Stem cells and Development. 18:741-748.

[46] Zuozhou Chen , C-H Christina Cheng, Junfang Zhang, Lixue Cao, Lei Chen, Longhai Zhou, Yudong Jin, Hua Ye, Cheng Deng, Zhonghua Dai, Qianghua Xu, Peng Hu, Shouhong Sun, Yu Shen, Liangbiao Chen*. (2008) Transcriptomic and genomic evolution under constant cold in Antarctic notothenioid fishes. Proc. Natl. Acad. Sci. USA. 105:12944-12949.

[47] Qianghua Xu , Chi-Hing Christina Cheng, Peng Hu, Hua Ye, Zuozhou Chen, Lixue Cao, Lei Chen, Yu Shen, Liangbiao Chen*. (2008) Adaptive evolution of hepcidin genes in antarctic notothenioid fishes. Mol. Biol. Evol. 25(6):1099-1112.

[48] Sihua Peng, Qianghua Xu, Xuefeng Bruce Ling, XiaoningPeng, Wei Du, Liangbiao Chen* (2003) Molecular classification of cancer types from microarray data using the combination of Genetic Algorithms and Support Vector Machines. FEBS Letters, 555:358-362.

[49] Chi-Hing C. Cheng, Liangbiao Chen, Thomas Near, Yumi Jin, (2003) Functional antifreeze glycoprotein genes in temperate-water New Zealand nototheniid fish infer an Antarctic origin. Mol. Biol. Evol. 20(11):1897-1908.

[50] Chi-Hing C. Cheng and Liangbiao Chen. Evolution of Antifreeze Glycoprotein. Nature. 1999, 401:443-444.

[51] Liangbiao Chen, Arthur L. DeVries, Chi-Hing C. Cheng. Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish. Proc. Natl. Acad. Sci. USA. 1997, 94:3811-3816.

[52] Liangbiao Chen, Arthur L. DeVries, Chi-Hing C. Cheng. Convergent evolution of antifreeze glycoproteins in Antarctic notothenioid fish and Arctic cod. Proc. Natl. Acad. Sci. USA. 1997, 94:3817-3822.

6. 专著

参编《鱼类低温适应的分子机制》，科学出版社，2017年5月第1版

7. 科研获奖：

陈良标(1/12)；鱼类抗冻蛋白基因的起源和低温适应的分子发育机制研究, 教育部高等学校科学研究优秀成果奖, 一等奖, 2020

陈良标(1/15)；极地鱼类适应性进化机制研究, 中国海洋学会, 海洋科学技术奖, 一等奖, 2019

8. 联系方式：

电话: 021-61900492

E-mail: lbchen@shou.edu.cn

联系地址: 上海市临港新城沪城环路999号，海洋科技大楼1001室

邮编: 201306