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发布日期:2020-04-27
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陈良标 教授

1.     个人基本情况:

陈良标,男,教授,博士生导师,中科院百人计划,国家杰出青年基金获得者。1996年获得美国University of Illinois at Urbana-Champaign分子生理学博士学位。19971999年,在美国National Institutes of Health做博士后研究。20002001年,在DoubletwistInc.USA)从事生物信息数据库工作。2001年回国任浙江大学教授。2003-2012年任中国科学院遗传与发育生物学研究所研究员。2013年起加盟上海海洋大学。现担任海洋生物科学国际联合研究中心主任和水产种质资源发掘与利用教育部重点实验室主任,先后主持科技部重点研发计划、国家基金委重点、面上等国家级项目10多项,NatureNature Communications PNASNucleic Acids ResearchGigascienceMolecular Biology and EvolutionStem Cell and Development 等领域重要杂志发表了一系列论文,在鱼类的适应性进化方面取得了重要成果。目前任《Aquaculture and Fisheries》副主编、《Journal of Genetics and Genomics》编委。已经培养博士16人,硕士研究生30余人,毕业的博士生中有的已经入选国家和地方人才计划。

 

2.     主要研究方向:

陈良标博士领导的创新小组的主要研究方向是动物进化与环境基因组学。主要通过高通量的基因组测序,分子生物学,生物信息学和细胞生物学等研究手段,阐述新基因起源的分子和进化机制, 鱼类环境适应的分子机制,基因组进化与环境的相互关系。目前实验室的研究方向有:

[1]极地鱼类适应极端环境的遗传与发育生物学机制;

[2]鱼类比较基因组学和分子进化;

[3]鱼类抗逆基因的挖掘和利用;

[4]生物信息学。

 

3.     主持的科研项目:

[1]上海市科委“一带一路”国际联合实验室项目:海洋生物科学国际联合实验室,2019-202219590750500300万元(含配套经费)

[2]国家重点研发计划项目:重要养殖生物对典型环境胁迫的响应机制和生理生态效应研究,2018-20222018YFD09006003617万元

[3]国家自然基金委国际(地区)合作与交流项目:鱼类免疫在极端环境下的进化,2017-201941761134050251万元

[4]国家自然基金委面上项目:抗冻蛋白基因LD4提高鱼类抗寒性能的分子机制研究,2016-20193157261165万元

[5]上海市教委研创新计划项目:以南极亚目鱼类为对象研究环境因子与基因组进化的相互作用及机制,2017-20222017-01-07-00-10-E00060300万元


 

4.     代表性论文:

[1] Jian Wang#, Yimeng Liu#, Shouwen Jiang, Wenhao Li, Lang Gui, Tao Zhou, Wanying Zhai, Zixuan Lin, Jiaying Lu, and Liangbiao Chen*. (2019).  Transcriptomic and epigenomic alterations of Nile tilapia gonads sexually reversed by high temperature. Aquaculture. 508:167-177.

[2] Qiao Huang#, Ruiqin Hu#, Hui zhu, Changlian Peng*,Liangbiao Chen*. (2019). The cold resistant activities ofmulti-domain type III antifreeze proteins from Antarctic eelpout Lycodichths dearborni revealed by transgenictobaccos, Aquaculture and Fisheries, Doi: 10.1016/j.aaf.2019.11.006

[3] Liangbiao Chen#, Ying Lu#, Wenhao Li#, Yandong Ren, Mengchao Yu, Shouwen Jiang, Yanxia Fu, Jian Wang, Sihua Peng, Kevin T. Bilyk, Katherine R. Murphy, Xuan Zhuang, Mathias Hune; Wanying Zhai, Wen Wang, Qianghua Xu*, Chi-Hing Christina Cheng*. (2019) Genomic bases for colonizing the freezing Southern Ocean revealed by the genomes of Antarctic toothfish and Patagonia robalo. GigaScience. 8, 1-16

[4] Tao Zhou#, Lang Gui#, Mingli Liu, Wenhao Li, Peng Hu, Daniel F.C. Duarte, Hongbo Niu and Liangbiao Chen*. (2019). Transcriptomic responses to low temperature stress in the Nile tilapia, Oreochromis niloticus. Fish Shellfish Immunology 84:1145-1156. doi: 10.1016/j.fsi.2018.10.023

[5] Putri RR and Chen L* (2018) Spatiotemporal control of zebrafish ( Danio rerio ) gene expression using a light-activated CRISPR activation system. Gene 677. (IF:2.498)

[6] Dongsheng Zhang#, Mengchao Yu#, Peng Hu#, Sihua Peng, Yimeng Liu, Weiwen Li, Congcong Wang, Shunping He, Wanying Zhai, Qianghua Xu, Liangbiao Chen*. (2017). Genetic Adaptation of the Schizothoracine Fishes to the Phased Uplifting of Qinghai-Tibetan Plateau. G3: Genes, Genomes, Genetics. 7 (4): 1267-1276 (IF:2.742)

[7] Mengchao Yu#, Dongsheng Zhang#, Peng Hu, Sihua Peng, Wenhao Li, Shunping He, Wanying Zhai, Qianghua Xu*, Liangbiao Chen*. (2017). Divergent adaptation to Qinghai-Tibetan Plateau implicated from transciptome study of Gymnocypris dobula and Schizothorax nukiangensis. Biochemical Systematics and Ecology. 71:97-105. (IF:0.847)

[8] Lixue Cao#, Qiao Huang#, Zhichao Wu#, Dong-dong Cao#, Zhanling Ma#, Qianghua Xu, Peng Hu, Yanxia Fu, Yu Shen, Jiulin Chan, Cong-zhao Zhou, Wanying Zhai, Liangbiao Chen*. (2016). Neofunctionalization of zona pellucida proteins enhances freeze-prevention in the eggs of Antarctic notothenioids. Nature Communications. 7: 12987 (IF:11.329)

[9] Peng Hu, Mingli Liu, Yimeng Liu, Jinfeng Wang, Dong Zhang, Hongbo Niu, Shouwen Jiang, Jian Wang, Dongsheng Zhang, Bingshe Han, Qianghua Xu andLiangbiao Chen*.(2016). Transcriptome comparison reveals a genetic network regulating the lower temperature limit in fish. Scientific Reports.DOI:10.1038/srep28952 (IF:5.228)

[10] Qianghua Xu*, Chi Zhang, Dongsheng Zhang, Huapeng Jiang, Sihua Peng, Yang Liu, Kai Zhao, Congcong Wang  andLiangbiao Chen*.(2016). Analysis of the erythropoietin of a Tibetan Plateau schizothoracine fish (Gymnocypris dobula) reveals enhanced cytoprotection function in hypoxic environments.BMC Evolutionary Biology.16 (1): 11 (IF:3.368)

[11] Hu P, Liu M, Zhang D, Wang J, Niu H, Liu Y, Wu Z, Han B, Zhai W, Shen Y, ChenL*.(2015). Global identification of the genetic networks and cis-regulatory elements of the cold response in zebrafish,Nucl. Acids Res. 43 (19): 9198-9213. (IF:9.112)

[12] Xu Q*, Cai C, Hu X, Liu Y, Guo Y, Hu P, Chen Z, Peng S, Zhang D, Jiang S, Wu Z, Chan J, Chen L*.(2015). Evolutionary suppression of erythropoiesis via the modulation of TGF-β signalling in an Antarctic icefish. MOL ECOL. 24(18): 4664-4678. (IF:6.494)

[13] Huang S, Cai M, Zheng Y, Zhou L, Wang Q, Chen L*.(2014). miR-888 in MCF-7 side population sphere cells directly targets E-cadherin. J Genet Genomics. 41(1):35-42. (IF:3.585)

[14] QianghuaXu, Guang Li, Lixue Cao, Zhongjun Wang, Hua Ye, Xiaoyin Chen, Xi Yang, Yiquan Wang, Liangbiao Chen*.(2012). Proteomic characterization and evolutionary analyses of zonapellucida domain-containing proteins in the egg coat of the cephalochordate, Branchiostomabelcheri. BMC Evolutionary Biology. 12 (1): 239 (IF:3.368)

[15] Gu Bin, Zhang Jiarong, Wang Shihao, Song Xiuli, Xu Cheng, Chen Liangbiao*, Zhang Ming* (2012). Aire promotes the self-renewal of embryonic stem cells through Lin28. Stem Cells and Development. 21: 2878-90. (IF:3.727)

[16] Yang R, Dai Z, Chen S, Chen L*.(2011). MicroRNA-mediated gene regulation plays a minor role in the transcriptomic plasticity of cold-acclimated zebrafish brain tissue. BMC Genomics. 12:605. (IF:3.986)

[17] Deng C, Cheng CH, Ye H, He X, Chen L*. (2010). Evolution of an antifreeze protein by neofunctionalization under escape from adaptive conflict. Proc Natl. Acad. Sci. USA. 107(50):21593-8. (IF:9.674)

[18] Dai Z., Chen Z., Hua Y., Wang Y., Peng S. and Chen L*. (2009). Characterization of microRNAs in cephalochordates reveals a correlation between miRNA repertoire homology and morphological similarity in chordate evolution. Evolution and Development. 11(1) 41-49.  (IF:2.716)

[19] Xie C, Huang H, Wei S, Song L, Zhang J, Ritchie R, Chen L, Zhang M and Chen Y (2009). A Comparison of Murine Smooth Muscle Cells Generated from Embryonic versus Induced Pluripotent Stem Cells. Stem cells and Development. 18:741-8. (IF:3.727)

[20] Chen Z#, Cheng CH#, Zhang J#, Cao L, Chen L, Zhou L, Jin Y, Ye H, Deng C, Dai Z, Xu Q, Hu P, Sun S, Shen Y, and Chen L*. (2008). Transcriptomic and genomic evolution under constant cold in Antarctic notothenioid fishes. Proc. Natl. Acad. Sci. USA. 105:12944-12949. (IF:9.674)

[21] Xu Q, Cheng CH, Hu P, Ye H, Chen Z, Cao L, Chen L, Shen Y, Chen L*. (2008). Adaptive evolution of hepcidin genes in antarctic notothenioid fishes. Mol. Biol. Evol. 25(6):1099-112. (IF:9.105)

[22] Sihua Peng, Qianghua Xu, Xuefeng Bruce Ling, XiaoningPeng, Wei Du, Liangbiao Chen* (2003). Molecular classification of cancer types from microarray data using the combination of Genetic Algorithms and Support Vector Machines. FEBS Letters, 555:358-62. (IF:3.169)

[23] Chi-Hing C. Cheng, Liangbiao Chen, Thomas Near, Yumi Jin, (2003). Functional antifreeze glycoprotein genes in temperate-water New Zealand nototheniid fish infer an Antarctic origin. Mol. Biol. Evol. 20(11):1897-908. (IF:9.105)

[24] Chi-Hing C. Cheng and Liangbiao Chen. Evolution of Antifreeze Glycoprotein. Nature. 1999, 401:443-444. (IF:41.456)

[25] Liangbiao Chen, Arthur L. DeVries, Chi-Hing C. Cheng. Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish. Proc. Natl. Acad. Sci. USA. 1997, 94:3811-3816. (IF:9.674)

[26] Liangbiao Chen, Arthur L. DeVries, Chi-Hing C. Cheng. Convergent evolution of antifreeze glycoproteins in Antarctic notothenioid fish and Arctic cod. Proc. Natl. Acad. Sci. USA. 1997, 94:3817-3822. (IF:9.674)

 

5.     专著

参编《鱼类低温适应的分子机制》,科学出版社,20175月第1

 

6.     科研工作获奖情况:

2019年,海洋科学技术奖, 一等奖,第一完成人

 

7.     联系方式:

电话: 021-61900492

E-mail: lbchen@shou.edu.cn

联系地址: 上海市临港新城沪城环路999号,上海海洋大学水产与生命学院

邮编: 201306

  

2020年4月更新)