1. 个人基本情况：

陈良标，博士，国家杰出青年基金获得者，入选“国家百千万人才工程”。现担任水产生物育种研究中心主任，先后主持科技部重点研发计划、国家基金委重点、面上等国家级项目10多项， 在Nature，Nature Communications，PNAS，Nucleic Acids Research，BMC Biology，Gigascience，Molecular Biology and Evolution，Stem Cell and Development 等领域重要杂志发表了一系列论文，在鱼类的适应性进化方面取得了重要成果。获得教育部高等学校科学研究优秀成果一等奖，海洋科学技术一等奖等奖励。担任中国水产学会水产生物技术与遗传育种专业委员会副主任委员，Zoological Research、Aquaculture and Fisheries、上海海洋大学学报、大连海洋大学学报等期刊编委。培养毕业的博士生中多人入选国家和地方人才计划。

陈良标博士领导的创新小组的主要研究方向是动物进化与环境基因组学。主要通过高通量的基因组测序，分子生物学，生物信息学和细胞生物学等研究手段，阐述新基因起源的分子和进化机制, 鱼类环境适应的分子机制，基因组进化与环境的相互关系。目前实验室的研究方向有：

[1] 极地鱼类适应极端环境的遗传与发育生物学机制；

[2]鱼类比较基因组学和分子进化；

[3]鱼类抗逆基因的挖掘和利用；

[4]人工智能的育种应用。

2. 主持的科研项目：

[1]国家重点研发计划项目：耐高温大口黑鲈和抗链球菌病罗非鱼新品种培育， 2022YFD2400800，2000万元 

[2]国家自然科学基金重点项目：耐寒河鲀品种的耐寒主效基因挖掘和应用研究制研究，32130109，288万元 

[3]国家重点研发计划项目：重要养殖生物对典型环境胁迫的响应机制和生理生态效应研究， 2018YFD0900600，3671万元 

[4]上海市科委“一带一路”国际联合实验室项目：海洋生物科学国际联合实验室， 19590750500，300万元

3. 代表性论文：

[1] Chan J, Wu Z, Liu M, Wang T, Liu H, Cao R, Li X, Li X, Zhan S, Cheng J, Xu Y, He M, Feng Y, Xu Q, Sun Y, Chen L, Hu P. Systematic enhancer mapping and functional analysis in zebrafish with optimized CRISPR interference. Nucleic Acids Res. 2025，53(22): gkaf1367. doi: 10.1093/nar/gkaf1367.

[2] Zhai X, Zhang M, Li K, Li W, Li X, Gao W, Sun Z, Huang D, Huang S, Liu M, Wu Z, Zou J, Chen L, Yang J, Hu P. Single-Cell Transcriptome Profiling Reveals Conserved IFNγ-IL8 Signaling-Induced Antibacterial Neutrophil States during Bacterial Infection. Adv Sci (Weinh). 2025，12(37): e04840. doi: 10.1002/advs.202504840.

[3] Zhang X, Peng M, Zhu J, Zhai X, Wei C, Jiao H, Wu Z, Huang S, Liu M, Li W, Yang W, Miao K, Xu Q, Chen L, Hu P. Benchmarking metabolic RNA labeling techniques for high-throughput single-cell RNA sequencing. Nat Commun. 2025，16(1): 5952. doi: 10.1038/s41467-025-61375-z.

[4] Huang S, Yan C, Xu Y, Qi J, Huang Q, Zhang M, Wu Z, Chan J, Liu M, Chen L, Hu P. Chromatin dynamics and transcriptional regulation of heat stress in an ectothermic fish. Proc Biol Sci. 2025，292(2049): 20250769. doi: 10.1098/rspb.2025.0769.

[5] Lu J, Huang S, Wei S, Cheng J, Li W, Fei Y, Yang J, Hu R, Huang S, Zhai W, Wu Z, Liu M, Xu Q, Hu P, Chen L. Heat inducible nuclear translocation of Kdm6bb drives temperature dependent sex reversal in Nile tilapia. PLoS Genet. 2025，21(4): e1011664. doi: 10.1371/journal.pgen.1011664.

[6] Zhai W, Li H, Liu M, Li L, Wang Z, Chen Q, Wang J, Chen L. Lignin degradation, metabolic profiling, and cold adaptation of Psychrobacter strain CLB018 isolated from the Antarctic fish Trematomus bernacchii. 3 Biotech. 2026，16(2): 69. doi: 10.1007/s13205-025-04623-9.

[7] Jiao H, Huang S, Zhang M, Huang Q, Yan C, Qi J, Cheng J, Xu Y, Zhai X, Li X, Zhan S, Li W, Wu Z, Chan J, Chen L, Hu P. Uncovering the chromatin-mediated transcriptional regulatory network governing cold stress responses in fish immune cells. J Genet Genomics. 2025，52(8): 1046-1057. doi: 10.1016/j.jgg.2025.01.008.

[8] Yang W, Peng M, Wang Y, Zhang X, Li W, Zhai X, Wu Z, Hu P, Chen L. Deletion of hepcidin disrupts iron homeostasis and hematopoiesis in zebrafish embryogenesis. Development. 2025，152(7): dev204307. doi: 10.1242/dev.204307.

[9] Hu R, Li G, Hu P, Niu H, Li W, Jiang S, Guan G, Xu Q, Liu M, Chen L. bmp10 maintains cardiac function by regulating iron homeostasis. J Genet Genomics. 2024，51(12): 1459-1473. doi: 10.1016/j.jgg.2024.10.003.

[10] Li W, Li Z, Bu M, Li J, Chen L. Metabolomic-based analysis reveals bile acid-mediated ovarian failure induced by low temperature in zebrafish. Zool Res. 2024，45(4): 791-804. doi: 10.24272/j.issn.2095-8137.2023.369.

[11] Wang J, Zhang J, Han S, Wang Y, Chen L. Establishment and characterization of a fin cell line from Takifugu obscurus and its application to fish immunology. J Fish Biol. 2025，106(4):1134-1147. doi: 10.1111/jfb.16021.

[12] Wang J, Han S, Zhang J, Luo Y, Wang Y, Chen L. Establishment and characterization of a gill cell line from Takifugu obscurus and transcriptome analysis of its gene expression profiles upon low temperature. Fish Shellfish Immunol. 2024，153: 109843. doi: 10.1016/j.fsi.2024.109843.

[13] Niu M, Whang H, Wu Z, Jiang S, Chen L. Deletion of Asb15b gene can lead to a significant decrease in zebrafish intermuscular bone. Gene. 2024，923: 148561. doi: 10.1016/j.gene.2024.148561.

[14] Gong X, Yan Q, Chen L. Transient receptor potential a1b regulates primordial germ cell numbers and sex differentiation in developing zebrafish. J Fish Biol. 2025， 106(3): 921-931. doi: 10.1111/jfb.16005.

[15] Wang Y, Wang H, Zhou Y, Hu L, Wan J, Yang J, Niu H, Hong X, Hu P, Chen L. Dusp1 regulates thermal tolerance limits in zebrafish by maintaining mitochondrial integrity. Zool Res. 2023，44(1): 126-141. doi: 10.24272/j.issn.2095-8137.2022.397.

[16] Han S, Wang J, Luo Y, Zhang J, Wang Y, Lin T, Xu B, Liu Q, Chen L. Cold exposure triggers distinct RNA editing, alternative splicing, and gene expression patterns in cold domestication pufferfish (Takifugu obscurus). Fish Shellfish Immunol. 2026，110972. doi: 10.1016/j.fsi.2025.110972.

[17] Wang J, Han S, Zhang J, Luo Y, Wang Y, Yan C, Chen L. Mitochondrial calcium uptake 1 (micu1) knockout ameliorates cold-induced cell death and inflammatory response by mediating mitochondrial homeostasis in fish. J Therm Biol. 2025，134: 104306. doi: 10.1016/j.jtherbio.2025.104306.

[18] Han S, Wang J, Lin T, Zhang J, Canario AVM, Liu Q, Chen L. Adaptive Evolution for Freshwater Adaptation in Coilia nasus by Directional Selection on Osmoregulation Genes. Mol Ecol. 2025 Oct;34(20): e70104. doi: 10.1111/mec.70104.

4. 联系方式：

电话: 021-61900492

联系地址: 上海市临港新城沪城环路999号，海洋科技大楼1001室

邮编: 201306