胡鹏，博士

上海海洋大学水产与生命学院教授、博士生导师

水产种质资源挖掘与利用教育部重点实验室主任

上海海洋大学青年教师工作委员会主任

国家青年人才计划入选者

邮箱：phu@shou.edu.cn 

学术网页: https://scholar.google.com/citations?hl=en&user=c9x6MQcAAAAJ

ORICD： 0009-0002-6840-7758

实验室网页：www.hulabshou.cn

项目支持

1. 十四五国家重点研发计划“海洋农业与淡水渔业科技创新”专项青年科学家项目，2023-2027, 200万元；主持

2. 国家自然科学基金生物育种专项，2024-2028， 100万元；主持

3. 国家自然科学基金面上项目，2024-2027， 50万元；主持

4. 国家自然科学基金青年项目，2023-2025，30万元；主持

5. 国家级青年人才计划，2022-2024，200万元；主持

6. 国家重点研发计划项目政府间国际科技创新合作重点专项；2024-2028，80万元；参与

7. 科技创新2030—重大项目，农业生物育种重大项目；2024-2026，45万元；参与

教育和学习经历

美国宾夕法尼亚大学，美国宾州费城市

· 2016年4月- 2021年12月   博士后, 医学院

· 合作导师：Hao Wu教授

上海海洋大学，中国上海市

· 2014年2月- 2016年4月    博士后, 生命学院

· 合作导师：陈良标教授

中国科学院遗传与发育生物学研究所，中国北京市

· 2009年9月- 2014年1月    理学博士，生物信息学

· 导师：陈良标研究员

中国农业大学，中国北京市

· 2007年9月- 2009年7月    农学硕士，动物遗传育种与繁殖

· 导师：王爱国教授

华中农业大学，中国湖北省武汉市

· 2003年9月- 2007年7月    农学学士，动物科学

工作经历

上海海洋大学，中国上海市

· 2021年12月- 至今

· 教授、博士生导师, 水产与生命学院

· 上海海洋大学青年教师工作委员会主任

· 水产种质资源挖掘与利用教育部重点实验室主任

研究方向

鱼类功能基因组学及抗逆抗病育种

学术兼职

国际干细胞学会会员

澳门青年科学家协会副会长

《水产学报》青年编委

Molecular Biology and Evolution、PNAS、Advanced Science、iMeta、Aquaculture等期刊审稿人

获奖情况

鱼类抗冻蛋白基因的起源和低温适应的分子发育机制研究，2021年教育部高等学校科学研究优秀成果奖（科学技术）一等奖（排名：12/12）

发表论文（*通讯作者，^#第一作者）

2025

Hepcidin Deletion Disrupts lron Homeostasis and Hematopoiesis in Zebrafish Embryogenesis.

Wenyi Yang, Mingjian Peng, Youquan Wang, Xiaowen Zhang, Wei Li, Xue Zhai, Zhichao Wu, Peng Hu*, Liangbiao Chen*

Development  PMID: 40110772

Constitutively active glucagon receptor drives high blood glucose in birds.

Chang Zhang, Xiangying Xiang, Jian Liu, Yongjie Huang, Jingwen Xue, Qian Sun, Song Leng, Shaobo Liu, Xuefei He, Peng Hu, Xiangjiang Zhan, Qiang Qiu, Shilong Yang, Jürgen Brosius, Cheng Deng*

Nature  PMID: 40031956

Tankyrase inhibitor IWR-1 modulates HIPPO and Transforming Growth Factor β signaling in primed bovine embryonic stem cells cultured on mouse embryonic fibroblasts.

Yao Xiao, Yujie Wang, Minghao Zhang, Yan Zhang, Zhihua Ju, Jinpeng Wang, Yaran Zhang, Chunhong Yang, Xiuge Wang, Qiang Jiang, Yaping Gao, Xiaochao Wei, Wenhao Liu, Yundong Gao, Peng Hu, Jinming Huang*

Theriogenology  PMID: 39613494

CS12192 Reverses Alopecia Areata by Selectively Targeting JAK3/JAK1/TBK1.

Hui Jin, Zongyang Li, Xinwen Li, Qiongqiong Xu, Beizhong Chen, Song Shan, Desi Pan, Peng Hu*,Shengjian Huang*

Advanced Biology   PMID: 40021475

Uncovering the chromatin-mediated transcriptional regulatory network governing cold stress responses in fish immune cells.

He Jiao, Songqian Huang*, Minghao Zhang, Qiao Huang, Chenyu Yan, Jingting Qi, Jiangbo Cheng, Yuan Xu, Xue Zhai, Xinwen Li, Siyao Zhan, Wei Li, Zhichao Wu, Jiulin Chan, Liangbiao Chen*, Peng Hu*

Journal of Genetics and Genomics   PMID: 39848465

scGO: interpretable deep neural network for cell status annotation and disease diagnosis.

You Wu, Pengfei Xu, Liyuan Wang, Shuai Liu, Yingnan Hou, Hui Lu, Peng Hu*, Xiaofei Li*, Xiang Yu*

Briefings in Bioinformatics   PMID: 39820437

2024

Intestinal DHA-PA-PG axis promotes digestive organ expansion by mediating usage of maternally deposited yolk lipids.

Zhengfang Chen, Mudan He, Houpeng Wang, Xuehui Li, Ruirui Qin, Ding Ye, Xue Zhai, Junwen Zhu, Quanqing Zhang, Peng Hu, Guanghou Shui, Yonghua Sun*

Nature Communications  PMID: 39528516

Genetically modified E. Coli secreting melanin (E.melanin) activates the astrocytic PSAP-GPR37L1 pathway and mitigates the pathogenesis of Parkinson's disease.

Weixian Kong, Yu Liu, Pu Ai, Yong Bi, Chaoguang Wei, Xiaoyang Guo, Zhenyu Cai, Ge Gao, Peng Hu, Jialin Zheng, Jianhui Liu*, Minfeng Huo*, Yuting Guan*, Qihui Wu*

Journal of Nanobiotechnology  PMID: 39523310

Optimized protocol for nuclei isolation from aquatic fish brain tissue for single-cell Genomic assays.

He Jiao , Jingting Qi, Yuan Xu, Chenyu Yan, Zhichao Wu, Liangbiao Chen, Songqian Huang*, Peng Hu*

Aquaculture and Fisheries 

bmp10 maintains cardiac function by regulating iron homeostasis.

Ruiqin Hu , Genfang Li , Peng Hu, Hongbo Niu , Wenhao Li , Shouwen Jiang , Guijun Guan , Qianghua Xu , Mingli Liu , Liangbiao Chen*

Journal of Genetics and Genomics  PMID: 39414074

Identification of two miRNAs regulating cardiomyocyte proliferation in an Antarctic icefish

Qianghua Xu*, Ruonan Jia, Fei Yang, Peng Hu, Xue Li, Saiya Ge, Shouwen Jiang, Jiulin Chan, Wanying Zhai, Liangbiao Chen*

iScience   PMID: 38939105

Integrated transcriptomic and epigenomic analyses to disclose the transcriptional regulatory mechanisms of lipid and energy metabolism under cold stress in grass carp.

Songqian Huang, Chenyu Yan, Yuan Xu, He Jiao, Minghao Zhang, Jiangbo Cheng, Wenting Wang, Zongbin Cui, Liangbiao Chen, Peng Hu*, Qianghua Xu*

Aquaculture   

A handheld isothermal fluorescence detector for duplex visualization of aquatic pathogens via enhanced one-pot LAMP-PfAgo assay.

Feibiao Pang, Tao Zhang, Fengyi Dai, Kaizheng Wang, Tianjiao Jiao, Zuoying Zhang, Liyi Zhang, Mingli Liu, Peng Hu*, Jinzhao Song*

Biosensors & Bioelectronics   PMID: 38518558

Sweat gland development requires an eccrine dermal niche and couples two epidermal programs.

Dingwall HL, Tomizawa RR, Aharoni A, Hu P, Qiu Q, Kokalario B, Martinez SM, Donahue JC, Aldea D, Mendoza M, Glass I, BDRL, Wu H, Kamberov YG

Developmental Cell  PMID: 38096824

2023

Joint single-cell profiling resolves 5mC and 5hmC and reveals their distinct gene regulatory effects.

Fabyanic E^#, Hu P^#(共同第一), Qiu Q^#, Wang T, Berrios KN, Flournoy J, Connolly DR, Zhou Z, Kohil RM, Wu H

Nature Biotechnology  PMID: 37640946

2022

Molecular landscapes of human hippocampal immature neurons across lifespan.

Zhou Y, Su Y, Li S, Kennedy BC, Zhang DY, Bond AM, Sun Y, Jacob F, Lu L, Hu P, Viaena A…, Ming G, Song H

Nature  PMID: 35794479

Neuronal Yin Yang1 in the prefrontal cortex regulates transcriptional and behavioral responses to chronic stress in mice. 

Kwon DY, Xu B, Hu P, Zhao YT, Beagan JA, Nofziger JH, Cui Y, Xu B, Zaitseva D, Phillips-Cremins JE, Blendy JA, Wu H, Zhou Z

Nature Communications  PMID: 35013139

Population genomics of an icefish reveals mechanisms of glacier-driven adaptive radiation in Antarctic notothenioids.

Lu Y, Li W, Li Y, Zhai W, Zhou X,Wu Z, Jiang S, Liu T, Wang H, Hu R, Zhou Y, Hu P, Guan G, Xu Q, Canario AVM, Chen L

BMC Biology  PMID: 36224580

2020

Massively parallel and time-resolved single-cell RNA sequencing with scNT-Seq.

Qiu Q^#, Hu P^#(共同第一), Qiu X, Govek KW, Camara PG, Wu H

Nature Methods  PMID: 32868927

Single cell transcriptomic analysis of the adult mouse pituitary reveals a novel multi-hormone cell cluster and physiologic demand-induced lineage plasticity.

Ho Y^#, Hu P^#(共同第一), Peel MT, Chen S, Camara PG, Epstein DJ, Wu H, Liebhaber SA

Protein & Cell  PMID: 32193873

The vertebrate- and testis- specific transmembrane protein C11ORF94 plays a critical role in sperm-oocyte membrane binding

Hao H, Shi B, Zhang J, Dai A, Li W, Chen H, Ji W, Gong C, Zhang C, Li J, Chen L, Yao B, Hu P, Yang H, Brosius J, Lai S, Shi Q & Deng C

Molecular Biomedicine  PMID: 36050562

MiR-202-3p determines embryo viability during mid-blastula transition

Hu R, Xu Y, Han B, Chen Y, Li W, Guan G, Hu P, Zhou Y, Xu Q, Chen L

Frontiers in Cell and Developmental Biology  PMID: 36003151

2019

Transcriptomic responses to low temperature stress in the Nile tilapia, Oreochromis niloticus.

Zhou T, Gui L, Liu M, Li W, Hu P, Duarte DFC, Niu H, Chen L

Fish & Shellfish Immunology  PMID: 30408600

2018

Single-nucleus transcriptomic survey of cell diversity and functional maturation in postnatal mammalian hearts.

Hu P^#, Liu J^#, Zhao J^#, Wilkins BJ, Lupino K, Wu H, Pei L

Genes & Development  PMID: 30254108

Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase.

Schutsky EK, DeNizio JE, Hu P, Liu MY, Nabel CS, Fabyanic EB, Hwang Y, Bushman FD, Wu H, Kohli RM

Nature Biotechnology  PMID: 30295673

GC bias lead to increased small amino acids and random coils of proteins in cold-water fishes.

Zhang D, Hu P, Liu T, Wang J, Jiang S, Xu Q, Chen L

BMC Genomics  PMID: 29720106

2017

Dissecting Cell-Type Composition and Activity-Dependent Transcriptional State in Mammalian Brains by Massively Parallel Single-Nucleus RNA-Seq.

Hu P^#, Fabyanic E^#, Kwon DY, Tang S, Zhou Z, Wu H

Molecular Cell  PMID: 29220646

Genetic Adaptation of Schizothoracine Fish to the Phased Uplifting of the Qinghai–Tibetan Plateau.

Zhang D^#, Yu M^#, Hu P^#(共同第一), Peng S, Liu Y, Li W, Wang C, He S, Zhai W, Xu Q, Chen L

G3: Genes|Genomes|Genetics  PMID: 28209761

Divergent adaptation to Qinghai-Tibetan Plateau implicated from transciptome study of Gymnocypris dobula and Schizothorax nukiangensis.

Yu M, Zhang D, Hu P, Peng S, Li W, He S, Zhai W, Xu Q, Chen L

Biochemical Systematics and Ecology

2016

Transcriptome comparison reveals a genetic network regulating the lower temperature limit in fish.

Hu P, Liu M, Liu Y, Wang J, Zhang D, Niu H, Jiang S, Wang J, Zhang D, Han B, Xu Q, Chen L

Scientific Reports  PMID: 27356472

Neofunctionalization of zona pellucida proteins enhances freeze-prevention in the eggs of Antarctic notothenioids.

Cao L, Huang Q, Wu Z, Cao D, Ma Z, Xu Q, Hu P, Fu Y, Shen Y, Chan J, Zhou C, Zhai W, Chen L

Nature Communications  PMID: 27698404

2015

Global identification of the genetic networks and cis-regulatory elements of the cold response in zebrafish.

Hu P, Liu M, Zhang D, Wang J, Niu H, Liu Y, Wu Z, Han B, Zhai W, Shen Y, Chen L

Nucleic Acids Research  PMID: 26227973

Evolutionary suppression of erythropoiesis via the modulation of TGF-β signalling in an Antarctic icefish.

Xu Q, Cai C, Hu X, Liu Y, Guo Y, Hu P, Chen Z, Peng S, Zhang D, Jiang S, Wu Z, Chan J, Chen L

Molecular Ecology  PMID: 26268413

实验室成员

实验室位于海洋科技大楼1018

工作人员：

黄松钱副教授、徐淑坦副教授、吴智超工程师、刘明丽博士后、产久林博士后、刘一萌讲师（访学）、刘涵宇科研助理

研究生：

张晓雯博三、翟雪博三、李新闻博二、魏朝广博二、李晓龙博二（兰州大学联合培养）、程江博博二（兰州大学联合培养）、贾若楠博二、黄巧博一、谢宏帅博一、张明皓博一

彭铭健硕三、赵文欣硕三、曹瑞萌硕三

占思瑶研二、朱江浩研二、王文婷研二、祁婧婷研二、严晨瑜研二

范旭研一、马静雯研一、陈虹如研一、祖金杰研一、黄丹研一、赵颖研一

王天铭本四、左诗雨本四、徐逸程本四、张钧睿本四、罗婧一本四、李鑫阳本二、郝悦彤本二

更新于2025-04-01